DegronMD

Uniprot ID: P12109

Source protein: Collagen alpha-1

Source gene: COL6A1

Class: LIG_APCC_ABBAyCdc20_2

Location: 938:944

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8204

ASA_SCORE: 10.1857

COIL: 0.0953

CONS_SCORE: 0.8475

DSS_SCORE: 0.334

HELIX: 0.0081

FCONS_SCORE: 1.356

RIG_SCORE: 0.8062

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G933S	TCGA-B5-A3FC	UCEC	TCGA	RLLLFSD	LIG_APCC_ABBAyCdc20_2	0.1944
p.G933S	DO41871	UCEC	ICGC	RLLLFSD	LIG_APCC_ABBAyCdc20_2	0.1944
p.Q948H	TCGA-CV-7090	HNSC	TCGA	RLLLFSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.Q948H	DO14238	HNSC	ICGC	RLLLFSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.A930V	TCGA-E6-A2P8	UCEC	TCGA	RLLLFSD	LIG_APCC_ABBAyCdc20_2	0.1111
p.A930V	DO40924	UCEC	ICGC	RLLLFSD	LIG_APCC_ABBAyCdc20_2	0.1111
p.A953V	TCGA-EY-A1GF	UCEC	TCGA	RLLLFSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.A953V	DO41704	UCEC	ICGC	RLLLFSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.A930S	DO228952	LICA	ICGC	RLLLFSD	LIG_APCC_ABBAyCdc20_2	0.1111
p.G933V	DO52655	MALY	ICGC	RLLLFSD	LIG_APCC_ABBAyCdc20_2	0.1944
p.A953T	DO224750	PACA	ICGC	RLLLFSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.A953T	SIDM01608	Endometrial Carcinoma	GDSC	RLLLFSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.R928H	SIDM00773	Non-Cancerous	GDSC	RLLLFSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.R928H	SIDM01126	Small Cell Lung Carcinoma	GDSC	RLLLFSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.R928H	SIDM00203	Ewing's Sarcoma	GDSC	RLLLFSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.R928H	SIDM00774	Breast Carcinoma	GDSC	RLLLFSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.S947L	SIDM00217	Colorectal Carcinoma	GDSC	RLLLFSD	LIG_APCC_ABBAyCdc20_2	0.25
p.S947L	ACH-000999	Colon/Colorectal Cancer	CCLE	RLLLFSD	LIG_APCC_ABBAyCdc20_2	0.25
p.P952A	SIDM01617	Endometrial Carcinoma	GDSC	RLLLFSD	LIG_APCC_ABBAyCdc20_2	0.1111
p.P952A	ACH-000994	Endometrial/Uterine Cancer	CCLE	RLLLFSD	LIG_APCC_ABBAyCdc20_2	0.1111
p.K937E	SIDM01664	Prostate Carcinoma	GDSC	RLLLFSD	LIG_APCC_ABBAyCdc20_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12109	Collagen alpha-1	LIG_APCC_ABBAyCdc20_2	938:944	RLLLFSD	APC,CDC20,FZR1	0.8204	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons