DegronMD

Uniprot ID: Q14667

Source protein: Protein KIAA0100

Source gene: KIAA0100

Class: LIG_APCC_ABBA_1

Location: 1779:1784

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6429

ASA_SCORE: 51.8167

COIL: 0.5977

CONS_SCORE: 0.6124

DSS_SCORE: 0.2071

HELIX: 0.3803

FCONS_SCORE: 1.2747

RIG_SCORE: 0.8205

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1774Y	TCGA-AG-A002	READ	TCGA	LLLHVE	LIG_APCC_ABBA_1	0.1944
p.I1775F	TCGA-EE-A181	SKCM	TCGA	LLLHVE	LIG_APCC_ABBA_1	0.2222
p.I1775F	DO37444	SKCM	ICGC	LLLHVE	LIG_APCC_ABBA_1	0.2222
p.H1782N	TCGA-EE-A20F	SKCM	TCGA	LLLHVE	LIG_APCC_ABBA_1	0.7423
p.H1782N	DO37961	SKCM	ICGC	LLLHVE	LIG_APCC_ABBA_1	0.7423
p.R1787W	TCGA-IB-7651	PAAD	TCGA	LLLHVE	LIG_APCC_ABBA_1	0.25
p.R1787W	DO46657	PAAD	ICGC	LLLHVE	LIG_APCC_ABBA_1	0.25
p.D1774E	DO229019	LICA	ICGC	LLLHVE	LIG_APCC_ABBA_1	0.1944
p.N1777K	DO229027	LICA	ICGC	LLLHVE	LIG_APCC_ABBA_1	0.2778
p.E1792Q	ACH-000455	Brain Cancer	CCLE	LLLHVE	LIG_APCC_ABBA_1	0.1111
p.A1773T	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	LLLHVE	LIG_APCC_ABBA_1	0.1667
p.A1773T	AN3-CA	endometrium	COSMIC	LLLHVE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14667	Protein KIAA0100	LIG_APCC_ABBA_1	1779:1784	LLLHVE	APC,CDC20,FZR1	0.6429	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons