DegronMD - Q14667(KIAA0100)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1509I	TCGA-49-AAQV	LUAD	TCGA	VNTPSFS	DEG_SCF_FBW7_1	1516:1522	Mutation rewiring degron network	0.1389
p.F1546I	TCGA-73-7499	LUAD	TCGA	FVVFTE	LIG_APCC_ABBA_1	1546:1551	Mutation altering degron motif	0.6304
p.F1546I	TCGA-73-7499	LUAD	TCGA	RFVVFTE	LIG_APCC_ABBAyCdc20_2	1545:1551	Mutation altering degron motif	0.6304
p.C1561F	TCGA-95-7562	LUAD	TCGA	FVVFTE	LIG_APCC_ABBA_1	1546:1551	Mutation rewiring degron network	0.0556
p.C1561F	TCGA-95-7562	LUAD	TCGA	RFVVFTE	LIG_APCC_ABBAyCdc20_2	1545:1551	Mutation rewiring degron network	0.0556
p.D1774Y	TCGA-AG-A002	READ	TCGA	LLLHVE	LIG_APCC_ABBA_1	1779:1784	Mutation rewiring degron network	0.1944
p.G1532C	TCGA-AP-A051	UCEC	TCGA	VNTPSFS	DEG_SCF_FBW7_1	1516:1522	Mutation rewiring degron network	0.0556
p.M1556T	TCGA-BR-4362	STAD	TCGA	FVVFTE	LIG_APCC_ABBA_1	1546:1551	Mutation rewiring degron network	0.1944
p.M1556T	TCGA-BR-4362	STAD	TCGA	RFVVFTE	LIG_APCC_ABBAyCdc20_2	1545:1551	Mutation rewiring degron network	0.1944
p.E1541K	TCGA-DK-A3X1	BLCA	TCGA	FVVFTE	LIG_APCC_ABBA_1	1546:1551	Mutation rewiring degron network	0.1944
p.E1541K	TCGA-DK-A3X1	BLCA	TCGA	RFVVFTE	LIG_APCC_ABBAyCdc20_2	1545:1551	Mutation rewiring degron network	0.2222
p.I1775F	TCGA-EE-A181	SKCM	TCGA	LLLHVE	LIG_APCC_ABBA_1	1779:1784	Mutation rewiring degron network	0.2222
p.I1775F	DO37444	SKCM	ICGC	LLLHVE	LIG_APCC_ABBA_1	1779:1784	Mutation rewiring degron network	0.2222
p.H1782N	TCGA-EE-A20F	SKCM	TCGA	LLLHVE	LIG_APCC_ABBA_1	1779:1784	Mutation altering degron motif	0.7423
p.H1782N	DO37961	SKCM	ICGC	LLLHVE	LIG_APCC_ABBA_1	1779:1784	Mutation altering degron motif	0.7423
p.R1787W	TCGA-IB-7651	PAAD	TCGA	LLLHVE	LIG_APCC_ABBA_1	1779:1784	Mutation rewiring degron network	0.25
p.R1787W	DO46657	PAAD	ICGC	LLLHVE	LIG_APCC_ABBA_1	1779:1784	Mutation rewiring degron network	0.25
p.G1531R	TCGA-QC-A7B5	SARC	TCGA	VNTPSFS	DEG_SCF_FBW7_1	1516:1522	Mutation rewiring degron network	0.0833
p.F1549L	TCGA-XF-A8HE	BLCA	TCGA	FVVFTE	LIG_APCC_ABBA_1	1546:1551	Mutation altering degron motif	0.6981
p.F1549L	TCGA-XF-A8HE	BLCA	TCGA	RFVVFTE	LIG_APCC_ABBAyCdc20_2	1545:1551	Mutation altering degron motif	0.6981
p.D1544N	TCGA-ZF-AA4V	BLCA	TCGA	FVVFTE	LIG_APCC_ABBA_1	1546:1551	Mutation rewiring degron network	0.2778
p.D1544N	TCGA-ZF-AA4V	BLCA	TCGA	RFVVFTE	LIG_APCC_ABBAyCdc20_2	1545:1551	Mutation rewiring degron network	0.3056
p.D1774E	DO229019	LICA	ICGC	LLLHVE	LIG_APCC_ABBA_1	1779:1784	Mutation rewiring degron network	0.1944
p.N1777K	DO229027	LICA	ICGC	LLLHVE	LIG_APCC_ABBA_1	1779:1784	Mutation rewiring degron network	0.2778
p.C1561Y	SIDM00820	Kidney Carcinoma	GDSC	FVVFTE	LIG_APCC_ABBA_1	1546:1551	Mutation rewiring degron network	0.0556
p.C1561Y	SIDM00820	Kidney Carcinoma	GDSC	RFVVFTE	LIG_APCC_ABBAyCdc20_2	1545:1551	Mutation rewiring degron network	0.0556
p.C1561Y	SIDM01049	Non-Cancerous	GDSC	FVVFTE	LIG_APCC_ABBA_1	1546:1551	Mutation rewiring degron network	0.0556
p.C1561Y	SIDM01049	Non-Cancerous	GDSC	RFVVFTE	LIG_APCC_ABBAyCdc20_2	1545:1551	Mutation rewiring degron network	0.0556
p.G1555D	SIDM01113	Other Sarcomas	GDSC	FVVFTE	LIG_APCC_ABBA_1	1546:1551	Mutation rewiring degron network	0.2222
p.G1555D	SIDM01113	Other Sarcomas	GDSC	RFVVFTE	LIG_APCC_ABBAyCdc20_2	1545:1551	Mutation rewiring degron network	0.2222
p.G1555D	ACH-000939	Sarcoma	CCLE	FVVFTE	LIG_APCC_ABBA_1	1546:1551	Mutation rewiring degron network	0.2222
p.G1555D	ACH-000939	Sarcoma	CCLE	RFVVFTE	LIG_APCC_ABBAyCdc20_2	1545:1551	Mutation rewiring degron network	0.2222
p.G1555D	SK-UT-1	soft tissue	COSMIC	FVVFTE	LIG_APCC_ABBA_1	1546:1551	Mutation rewiring degron network	0.2222
p.G1555D	SK-UT-1	soft tissue	COSMIC	RFVVFTE	LIG_APCC_ABBAyCdc20_2	1545:1551	Mutation rewiring degron network	0.2222
p.G1531E	SIDM00801	Melanoma	GDSC	VNTPSFS	DEG_SCF_FBW7_1	1516:1522	Mutation rewiring degron network	0.0833
p.G1531E	ACH-000008	Skin Cancer	CCLE	VNTPSFS	DEG_SCF_FBW7_1	1516:1522	Mutation rewiring degron network	0.0833
p.G1531E	A101D	skin	COSMIC	VNTPSFS	DEG_SCF_FBW7_1	1516:1522	Mutation rewiring degron network	0.0833
p.R1515C	SIDM00006	Other Solid Cancers	GDSC	VNTPSFS	DEG_SCF_FBW7_1	1516:1522	Mutation rewiring degron network	0.3056
p.R1515C	ACH-001552	Skin Cancer	CCLE	VNTPSFS	DEG_SCF_FBW7_1	1516:1522	Mutation rewiring degron network	0.3056
p.R1515C	MCC26	skin	COSMIC	VNTPSFS	DEG_SCF_FBW7_1	1516:1522	Mutation rewiring degron network	0.3056
p.S1530P	SIDM01617	Endometrial Carcinoma	GDSC	VNTPSFS	DEG_SCF_FBW7_1	1516:1522	Mutation rewiring degron network	0.1111
p.S1530P	ACH-000994	Endometrial/Uterine Cancer	CCLE	VNTPSFS	DEG_SCF_FBW7_1	1516:1522	Mutation rewiring degron network	0.1111
p.E1792Q	ACH-000455	Brain Cancer	CCLE	LLLHVE	LIG_APCC_ABBA_1	1779:1784	Mutation rewiring degron network	0.1111
p.A1773T	GR-ST	haematopoietic and lymphoid tissue	COSMIC	LLLHVE	LIG_APCC_ABBA_1	1779:1784	Mutation rewiring degron network	0.1667
p.A1773T	AN3-CA	endometrium	COSMIC	LLLHVE	LIG_APCC_ABBA_1	1779:1784	Mutation rewiring degron network	0.1667
p.V1539A	VA-ES-BJ	bone	COSMIC	FVVFTE	LIG_APCC_ABBA_1	1546:1551	Mutation rewiring degron network	0.1389
p.V1539A	VA-ES-BJ	bone	COSMIC	RFVVFTE	LIG_APCC_ABBAyCdc20_2	1545:1551	Mutation rewiring degron network	0.1667
p.R1518Q	22RV1	prostate	COSMIC	VNTPSFS	DEG_SCF_FBW7_1	1516:1522	Mutation altering degron motif	0.7329
p.L1509F	MN-60	haematopoietic and lymphoid tissue	COSMIC	VNTPSFS	DEG_SCF_FBW7_1	1516:1522	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIAA0100

UniProt ID: Q14667

Entrez ID: 9703

Protein name: Protein KIAA0100 (Antigen MLAA-22) (Breast cancer-overexpressed gene 1 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIAA0100 in