DegronMD

Uniprot ID: Q14667

Source protein: Protein KIAA0100

Source gene: KIAA0100

Class: DEG_SCF_FBW7_1

Location: 1516:1522

E3 ligase: FBXW7

DEGRON score: 0.9949

ASA_SCORE: 86.4143

COIL: 0.9511

CONS_SCORE: 0.2862

DSS_SCORE: 0.7257

HELIX: 0.0209

FCONS_SCORE: 1.0699

RIG_SCORE: 0.5949

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1509I	TCGA-49-AAQV	LUAD	TCGA	VNTPSFS	DEG_SCF_FBW7_1	0.1389
p.G1532C	TCGA-AP-A051	UCEC	TCGA	VNTPSFS	DEG_SCF_FBW7_1	0.0556
p.G1531R	TCGA-QC-A7B5	SARC	TCGA	VNTPSFS	DEG_SCF_FBW7_1	0.0833
p.G1531E	SIDM00801	Melanoma	GDSC	VNTPSFS	DEG_SCF_FBW7_1	0.0833
p.G1531E	ACH-000008	Skin Cancer	CCLE	VNTPSFS	DEG_SCF_FBW7_1	0.0833
p.G1531E	A101D	skin	COSMIC	VNTPSFS	DEG_SCF_FBW7_1	0.0833
p.R1515C	SIDM00006	Other Solid Cancers	GDSC	VNTPSFS	DEG_SCF_FBW7_1	0.3056
p.R1515C	ACH-001552	Skin Cancer	CCLE	VNTPSFS	DEG_SCF_FBW7_1	0.3056
p.R1515C	MCC26	skin	COSMIC	VNTPSFS	DEG_SCF_FBW7_1	0.3056
p.S1530P	SIDM01617	Endometrial Carcinoma	GDSC	VNTPSFS	DEG_SCF_FBW7_1	0.1111
p.S1530P	ACH-000994	Endometrial/Uterine Cancer	CCLE	VNTPSFS	DEG_SCF_FBW7_1	0.1111
p.R1518Q	22RV1	prostate	COSMIC	VNTPSFS	DEG_SCF_FBW7_1	0.7329
p.L1509F	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	VNTPSFS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14667	Protein KIAA0100	DEG_SCF_FBW7_1	1516:1522	VNTPSFS	FBXW7	0.9949	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons