DegronMD

Uniprot ID: Q14667

Source protein: Protein KIAA0100

Source gene: KIAA0100

Class: LIG_APCC_ABBAyCdc20_2

Location: 1545:1551

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7353

ASA_SCORE: 80.7857

COIL: 0.4779

CONS_SCORE: 0.3145

DSS_SCORE: 0.3859

HELIX: 0.1561

FCONS_SCORE: 0.88

RIG_SCORE: 0.8872

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F1546I	TCGA-73-7499	LUAD	TCGA	RFVVFTE	LIG_APCC_ABBAyCdc20_2	0.6304
p.C1561F	TCGA-95-7562	LUAD	TCGA	RFVVFTE	LIG_APCC_ABBAyCdc20_2	0.0556
p.M1556T	TCGA-BR-4362	STAD	TCGA	RFVVFTE	LIG_APCC_ABBAyCdc20_2	0.1944
p.E1541K	TCGA-DK-A3X1	BLCA	TCGA	RFVVFTE	LIG_APCC_ABBAyCdc20_2	0.2222
p.F1549L	TCGA-XF-A8HE	BLCA	TCGA	RFVVFTE	LIG_APCC_ABBAyCdc20_2	0.6981
p.D1544N	TCGA-ZF-AA4V	BLCA	TCGA	RFVVFTE	LIG_APCC_ABBAyCdc20_2	0.3056
p.C1561Y	SIDM00820	Kidney Carcinoma	GDSC	RFVVFTE	LIG_APCC_ABBAyCdc20_2	0.0556
p.C1561Y	SIDM01049	Non-Cancerous	GDSC	RFVVFTE	LIG_APCC_ABBAyCdc20_2	0.0556
p.G1555D	SIDM01113	Other Sarcomas	GDSC	RFVVFTE	LIG_APCC_ABBAyCdc20_2	0.2222
p.G1555D	ACH-000939	Sarcoma	CCLE	RFVVFTE	LIG_APCC_ABBAyCdc20_2	0.2222
p.G1555D	SK-UT-1	soft_tissue	COSMIC	RFVVFTE	LIG_APCC_ABBAyCdc20_2	0.2222
p.V1539A	VA-ES-BJ	bone	COSMIC	RFVVFTE	LIG_APCC_ABBAyCdc20_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14667	Protein KIAA0100	LIG_APCC_ABBAyCdc20_2	1545:1551	RFVVFTE	APC,CDC20,FZR1	0.7353	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons