DegronMD

Uniprot ID: P31994

Source protein: Low affinity immunoglobulin gamma Fc region receptor II-b

Source gene: FCGR2B

Class: LIG_APCC_ABBA_1

Location: 294:299

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9561

ASA_SCORE: 66.0833

COIL: 0.5352

CONS_SCORE: 0.5483

DSS_SCORE: 0.633

HELIX: 0.0322

FCONS_SCORE: 1.0876

RIG_SCORE: 0.7617

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A300V	TCGA-A6-6781	COAD	TCGA	LLMHPD	LIG_APCC_ABBA_1	0.3056
p.A300V	DO8447	COAD	ICGC	LLMHPD	LIG_APCC_ABBA_1	0.3056
p.R309H	TCGA-AP-A056	UCEC	TCGA	LLMHPD	LIG_APCC_ABBA_1	0.0556
p.R309H	DO43971	UCEC	ICGC	LLMHPD	LIG_APCC_ABBA_1	0.0556
p.R309H	SIDM01608	Endometrial Carcinoma	GDSC	LLMHPD	LIG_APCC_ABBA_1	0.0556
p.G285V	TCGA-BF-A1Q0	SKCM	TCGA	LLMHPD	LIG_APCC_ABBA_1	0.0833
p.G285V	DO47374	SKCM	ICGC	LLMHPD	LIG_APCC_ABBA_1	0.0833
p.L295I	TCGA-FI-A2D5	UCEC	TCGA	LLMHPD	LIG_APCC_ABBA_1	0.6063
p.L295I	DO41331	UCEC	ICGC	LLMHPD	LIG_APCC_ABBA_1	0.6063
p.H297D	DO52653	MALY	ICGC	LLMHPD	LIG_APCC_ABBA_1	0.7688
p.N308S	SIDM00789	Colorectal Carcinoma	GDSC	LLMHPD	LIG_APCC_ABBA_1	0.0833
p.N308S	ACH-001091	Colon/Colorectal Cancer	CCLE	LLMHPD	LIG_APCC_ABBA_1	0.0833
p.N308S	HCT-15	large_intestine	COSMIC	LLMHPD	LIG_APCC_ABBA_1	0.0833
p.L295P	SIDM00590	Oral Cavity Carcinoma	GDSC	LLMHPD	LIG_APCC_ABBA_1	0.6471
p.L295P	HSC-2	upper_aerodigestive_tract	COSMIC	LLMHPD	LIG_APCC_ABBA_1	0.6471
p.A286V	SIDM00683	Prostate Carcinoma	GDSC	LLMHPD	LIG_APCC_ABBA_1	0.1111
p.A286V	LNCaP-Clone-FGC	prostate	COSMIC	LLMHPD	LIG_APCC_ABBA_1	0.1111
p.R290H	ACH-000990	Endometrial/Uterine Cancer	CCLE	LLMHPD	LIG_APCC_ABBA_1	0.2222
p.N289S	ACH-000997	Colon/Colorectal Cancer	CCLE	LLMHPD	LIG_APCC_ABBA_1	0.1944
p.N289S	ACH-001061	Colon/Colorectal Cancer	CCLE	LLMHPD	LIG_APCC_ABBA_1	0.1944
p.N289S	HCT-15	large_intestine	COSMIC	LLMHPD	LIG_APCC_ABBA_1	0.1944
p.L288P	HSC-2	upper_aerodigestive_tract	COSMIC	LLMHPD	LIG_APCC_ABBA_1	0.1667
p.N301S	HCT-15	large_intestine	COSMIC	LLMHPD	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P31994	Low affinity immunoglobulin gamma Fc region receptor II-b	LIG_APCC_ABBA_1	294:299	LLMHPD	APC,CDC20,FZR1	0.9561	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons