DegronMD - P31994(FCGR2B)

GO - Biological processes (BP): antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; cell surface receptor signaling pathway [GO:0007166]; cellular response to amyloid-beta [GO:1904646]; cellular response to molecule of bacterial origin [GO:0071219]; cerebellum development [GO:0021549]; defense response [GO:0006952]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; follicular B cell differentiation [GO:0002316]; follicular dendritic cell activation [GO:0002266]; immune complex clearance by monocytes and macrophages [GO:0002436]; immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]; inflammatory response [GO:0006954]; mature B cell differentiation involved in immune response [GO:0002313]; negative regulation of acute inflammatory response to antigenic stimulus [GO:0002865]; negative regulation of antibody-dependent cellular cytotoxicity [GO:0001814]; negative regulation of B cell activation [GO:0050869]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of B cell receptor signaling pathway [GO:0050859]; negative regulation of cytokine production [GO:0001818]; negative regulation of cytotoxic T cell degranulation [GO:0043318]; negative regulation of dendritic cell antigen processing and presentation [GO:0002605]; negative regulation of dendritic cell differentiation [GO:2001199]; negative regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002924]; negative regulation of immune response [GO:0050777]; negative regulation of immunoglobulin production [GO:0002638]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of macrophage activation [GO:0043031]; negative regulation of neutrophil activation [GO:1902564]; negative regulation of phagocytosis [GO:0050765]; negative regulation of type I hypersensitivity [GO:0001811]; phagocytosis, engulfment [GO:0006911]; positive regulation of humoral immune response [GO:0002922]; positive regulation of JNK cascade [GO:0046330]; positive regulation of neuron death [GO:1901216]; positive regulation of phagocytosis [GO:0050766]; positive regulation of response to endoplasmic reticulum stress [GO:1905898]; receptor-mediated endocytosis [GO:0006898]; regulation of adaptive immune response [GO:0002819]; regulation of B cell antigen processing and presentation [GO:0002622]; regulation of dendritic spine maintenance [GO:1902950]; regulation of immune complex clearance by monocytes and macrophages [GO:0090264]; regulation of immune response [GO:0050776]; regulation of innate immune response [GO:0045088]; regulation of signaling receptor activity [GO:0010469]; response to bacterium [GO:0009617]; signal transduction [GO:0007165] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G198E	TCGA-06-5416	GBM	TCGA	NIGYTLYSSKP	CBL_PTK	199:209	Mutation rewiring degron network	0.3056
p.G198E	DO10880	GBM	ICGC	NIGYTLYSSKP	CBL_PTK	199:209	Mutation rewiring degron network	0.3056
p.A300V	TCGA-A6-6781	COAD	TCGA	LLMHPD	LIG_APCC_ABBA_1	294:299	Mutation rewiring degron network	0.3056
p.A300V	DO8447	COAD	ICGC	LLMHPD	LIG_APCC_ABBA_1	294:299	Mutation rewiring degron network	0.3056
p.S206P	TCGA-AP-A051	UCEC	TCGA	NIGYTLYSSKP	CBL_PTK	199:209	Mutation altering degron motif	0.5641
p.S206P	DO42673	UCEC	ICGC	NIGYTLYSSKP	CBL_PTK	199:209	Mutation altering degron motif	0.5641
p.R309H	TCGA-AP-A056	UCEC	TCGA	LLMHPD	LIG_APCC_ABBA_1	294:299	Mutation rewiring degron network	0.0556
p.R309H	DO43971	UCEC	ICGC	LLMHPD	LIG_APCC_ABBA_1	294:299	Mutation rewiring degron network	0.0556
p.R309H	SIDM01608	Endometrial Carcinoma	GDSC	LLMHPD	LIG_APCC_ABBA_1	294:299	Mutation rewiring degron network	0.0556
p.P209H	TCGA-AX-A1C5	UCEC	TCGA	NIGYTLYSSKP	CBL_PTK	199:209	Mutation altering degron motif	0.7694
p.P209H	DO41422	UCEC	ICGC	NIGYTLYSSKP	CBL_PTK	199:209	Mutation altering degron motif	0.7694
p.Y202H	TCGA-AX-A2HA	UCEC	TCGA	NIGYTLYSSKP	CBL_PTK	199:209	Mutation altering degron motif	0.6118
p.Y202H	DO42504	UCEC	ICGC	NIGYTLYSSKP	CBL_PTK	199:209	Mutation altering degron motif	0.6118
p.G285V	TCGA-BF-A1Q0	SKCM	TCGA	LLMHPD	LIG_APCC_ABBA_1	294:299	Mutation rewiring degron network	0.0833
p.G285V	DO47374	SKCM	ICGC	LLMHPD	LIG_APCC_ABBA_1	294:299	Mutation rewiring degron network	0.0833
p.Q215K	TCGA-EE-A3AG	SKCM	TCGA	NIGYTLYSSKP	CBL_PTK	199:209	Mutation rewiring degron network	0.1667
p.Q215K	DO37471	SKCM	ICGC	NIGYTLYSSKP	CBL_PTK	199:209	Mutation rewiring degron network	0.1667
p.L295I	TCGA-FI-A2D5	UCEC	TCGA	LLMHPD	LIG_APCC_ABBA_1	294:299	Mutation altering degron motif	0.6063
p.L295I	DO41331	UCEC	ICGC	LLMHPD	LIG_APCC_ABBA_1	294:299	Mutation altering degron motif	0.6063
p.Y205F	DO51019	LAML	ICGC	NIGYTLYSSKP	CBL_PTK	199:209	Mutation altering degron motif	0.7528
p.Y205F	DO229151	THCA	ICGC	NIGYTLYSSKP	CBL_PTK	199:209	Mutation altering degron motif	0.7528
p.H297D	DO52653	MALY	ICGC	LLMHPD	LIG_APCC_ABBA_1	294:299	Mutation altering degron motif	0.7688
p.T203M	SIDM00144	Non-Small Cell Lung Carcinoma	GDSC	NIGYTLYSSKP	CBL_PTK	199:209	Mutation altering degron motif	0.6312
p.N308S	SIDM00789	Colorectal Carcinoma	GDSC	LLMHPD	LIG_APCC_ABBA_1	294:299	Mutation rewiring degron network	0.0833
p.N308S	ACH-001091	Colon/Colorectal Cancer	CCLE	LLMHPD	LIG_APCC_ABBA_1	294:299	Mutation rewiring degron network	0.0833
p.N308S	HCT-15	large intestine	COSMIC	LLMHPD	LIG_APCC_ABBA_1	294:299	Mutation rewiring degron network	0.0833
p.L295P	SIDM00590	Oral Cavity Carcinoma	GDSC	LLMHPD	LIG_APCC_ABBA_1	294:299	Mutation altering degron motif	0.6471
p.L295P	HSC-2	upper aerodigestive tract	COSMIC	LLMHPD	LIG_APCC_ABBA_1	294:299	Mutation altering degron motif	0.6471
p.A286V	SIDM00683	Prostate Carcinoma	GDSC	LLMHPD	LIG_APCC_ABBA_1	294:299	Mutation rewiring degron network	0.1111
p.A286V	LNCaP-Clone-FGC	prostate	COSMIC	LLMHPD	LIG_APCC_ABBA_1	294:299	Mutation rewiring degron network	0.1111
p.R290H	ACH-000990	Endometrial/Uterine Cancer	CCLE	LLMHPD	LIG_APCC_ABBA_1	294:299	Mutation rewiring degron network	0.2222
p.N289S	ACH-000997	Colon/Colorectal Cancer	CCLE	LLMHPD	LIG_APCC_ABBA_1	294:299	Mutation rewiring degron network	0.1944
p.N289S	ACH-001061	Colon/Colorectal Cancer	CCLE	LLMHPD	LIG_APCC_ABBA_1	294:299	Mutation rewiring degron network	0.1944
p.N289S	HCT-15	large intestine	COSMIC	LLMHPD	LIG_APCC_ABBA_1	294:299	Mutation rewiring degron network	0.1944
p.L288P	HSC-2	upper aerodigestive tract	COSMIC	LLMHPD	LIG_APCC_ABBA_1	294:299	Mutation rewiring degron network	0.1667
p.N301S	HCT-15	large intestine	COSMIC	LLMHPD	LIG_APCC_ABBA_1	294:299	Mutation rewiring degron network	0.2778

Kaplan plot for FCGR2B in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FCGR2B

UniProt ID: P31994

Entrez ID: 2213

Protein name: Low affinity immunoglobulin gamma Fc region receptor II-b (IgG Fc receptor II-b) (CDw32) (Fc-gamma RII-b) (Fc-gamma-RIIb) (FcRII-b) (CD antigen CD32)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for FCGR2B in