DegronMD

Uniprot ID: P31994

Source protein: Low affinity immunoglobulin gamma Fc region receptor II-b

Source gene: FCGR2B

Class: CBL_PTK

Location: 199:209

E3 ligase: CBL

DEGRON score: 0.6236

ASA_SCORE: 87.9545

COIL: 0.4798

CONS_SCORE: 0.5841

DSS_SCORE: 0.2012

HELIX: 0.007

FCONS_SCORE: 0.7935

RIG_SCORE: 0.7889

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G198E	TCGA-06-5416	GBM	TCGA	NIGYTLYSSKP	CBL_PTK	0.3056
p.G198E	DO10880	GBM	ICGC	NIGYTLYSSKP	CBL_PTK	0.3056
p.S206P	TCGA-AP-A051	UCEC	TCGA	NIGYTLYSSKP	CBL_PTK	0.5641
p.S206P	DO42673	UCEC	ICGC	NIGYTLYSSKP	CBL_PTK	0.5641
p.P209H	TCGA-AX-A1C5	UCEC	TCGA	NIGYTLYSSKP	CBL_PTK	0.7694
p.P209H	DO41422	UCEC	ICGC	NIGYTLYSSKP	CBL_PTK	0.7694
p.Y202H	TCGA-AX-A2HA	UCEC	TCGA	NIGYTLYSSKP	CBL_PTK	0.6118
p.Y202H	DO42504	UCEC	ICGC	NIGYTLYSSKP	CBL_PTK	0.6118
p.Q215K	TCGA-EE-A3AG	SKCM	TCGA	NIGYTLYSSKP	CBL_PTK	0.1667
p.Q215K	DO37471	SKCM	ICGC	NIGYTLYSSKP	CBL_PTK	0.1667
p.Y205F	DO51019	LAML	ICGC	NIGYTLYSSKP	CBL_PTK	0.7528
p.Y205F	DO229151	THCA	ICGC	NIGYTLYSSKP	CBL_PTK	0.7528
p.T203M	SIDM00144	Non-Small Cell Lung Carcinoma	GDSC	NIGYTLYSSKP	CBL_PTK	0.6312

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P31994	Low affinity immunoglobulin gamma Fc region receptor II-b	CBL_PTK	199:209	NIGYTLYSSKP	CBL	0.6236	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons