DegronMD

Uniprot ID: Q3KQU3

Source protein: MAP7 domain-containing protein 1

Source gene: MAP7D1

Class: LIG_APCC_ABBA_1

Location: 817:822

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.812

ASA_SCORE: 64.3333

COIL: 0.6218

CONS_SCORE: 0.3301

DSS_SCORE: 0.3435

HELIX: 0.2455

FCONS_SCORE: 0.9805

RIG_SCORE: 0.8087

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A823V	TCGA-VQ-A8P2	STAD	TCGA	LLPFAE	LIG_APCC_ABBA_1	0.3056
p.E822K	TCGA-XF-A9SH	BLCA	TCGA	LLPFAE	LIG_APCC_ABBA_1	0.7022
p.A821V	SIDM00793	Burkitt's Lymphoma	GDSC	LLPFAE	LIG_APCC_ABBA_1	0.5825
p.E824K	SIDM01503	Small Cell Lung Carcinoma	GDSC	LLPFAE	LIG_APCC_ABBA_1	0.2778
p.E824K	ACH-000844	Lung Cancer	CCLE	LLPFAE	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3KQU3	MAP7 domain-containing protein 1	LIG_APCC_ABBA_1	817:822	LLPFAE	APC,CDC20,FZR1	0.812	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons