DegronMD - Q3KQU3(MAP7D1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D46H	TCGA-06-1802	GBM	TCGA	VPDTPPDT	DEG_SCF_FBW7_1	44:51	Mutation altering degron motif	0.6577
p.D46H	DO12100	GBM	ICGC	VPDTPPDT	DEG_SCF_FBW7_1	44:51	Mutation altering degron motif	0.6577
p.V297L	TCGA-A3-A8OU	KIRC	TCGA	LMTPTLS	DEG_SCF_FBW7_1	300:306	Mutation rewiring degron network	0.25
p.V297L	DO219231	KIRC	ICGC	LMTPTLS	DEG_SCF_FBW7_1	300:306	Mutation rewiring degron network	0.25
p.V297L	DO229041	LICA	ICGC	LMTPTLS	DEG_SCF_FBW7_1	300:306	Mutation rewiring degron network	0.25
p.M55I	TCGA-BT-A20O	BLCA	TCGA	VPDTPPDT	DEG_SCF_FBW7_1	44:51	Mutation rewiring degron network	0.2222
p.M55I	DO460	BLCA	ICGC	VPDTPPDT	DEG_SCF_FBW7_1	44:51	Mutation rewiring degron network	0.2222
p.P35L	TCGA-CJ-4637	KIRC	TCGA	VPDTPPDT	DEG_SCF_FBW7_1	44:51	Mutation rewiring degron network	0.0833
p.P35L	DO16495	KIRC	ICGC	VPDTPPDT	DEG_SCF_FBW7_1	44:51	Mutation rewiring degron network	0.0833
p.E293Q	TCGA-DK-A3WW	BLCA	TCGA	LMTPTLS	DEG_SCF_FBW7_1	300:306	Mutation rewiring degron network	0.1389
p.A291T	TCGA-EO-A22U	UCEC	TCGA	LMTPTLS	DEG_SCF_FBW7_1	300:306	Mutation rewiring degron network	0.0833
p.W292C	TCGA-ER-A19B	SKCM	TCGA	LMTPTLS	DEG_SCF_FBW7_1	300:306	Mutation rewiring degron network	0.1111
p.T302M	TCGA-FR-A726	SKCM	TCGA	LMTPTLS	DEG_SCF_FBW7_1	300:306	Mutation altering degron motif	0.8534
p.T302M	SIDM00282	Colorectal Carcinoma	GDSC	LMTPTLS	DEG_SCF_FBW7_1	300:306	Mutation altering degron motif	0.8534
p.T302M	ACH-000998	Colon/Colorectal Cancer	CCLE	LMTPTLS	DEG_SCF_FBW7_1	300:306	Mutation altering degron motif	0.8534
p.T302M	CW-2	large intestine	COSMIC	LMTPTLS	DEG_SCF_FBW7_1	300:306	Mutation altering degron motif	0.8534
p.D298N	TCGA-V1-A9OY	PRAD	TCGA	LMTPTLS	DEG_SCF_FBW7_1	300:306	Mutation rewiring degron network	0.2778
p.D298N	DO219389	PRAD	ICGC	LMTPTLS	DEG_SCF_FBW7_1	300:306	Mutation rewiring degron network	0.2778
p.A823V	TCGA-VQ-A8P2	STAD	TCGA	LLPFAE	LIG_APCC_ABBA_1	817:822	Mutation rewiring degron network	0.3056
p.P48A	TCGA-WK-A8XQ	SARC	TCGA	VPDTPPDT	DEG_SCF_FBW7_1	44:51	Mutation altering degron motif	0.7503
p.P48A	DO220295	SARC	ICGC	VPDTPPDT	DEG_SCF_FBW7_1	44:51	Mutation altering degron motif	0.7503
p.R299C	TCGA-WS-AB45	COAD	TCGA	LMTPTLS	DEG_SCF_FBW7_1	300:306	Mutation rewiring degron network	0.3056
p.E822K	TCGA-XF-A9SH	BLCA	TCGA	LLPFAE	LIG_APCC_ABBA_1	817:822	Mutation altering degron motif	0.7022
p.R314H	DO229363	BTCA	ICGC	LMTPTLS	DEG_SCF_FBW7_1	300:306	Mutation rewiring degron network	0.1111
p.R314H	DO230309	COCA	ICGC	LMTPTLS	DEG_SCF_FBW7_1	300:306	Mutation rewiring degron network	0.1111
p.A700T	DO49095	COAD	ICGC	RRKRLEEIM	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.1111
p.A700T	DO233651	GACA	ICGC	RRKRLEEIM	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.1111
p.A700T	DO41199	UCEC	ICGC	RRKRLEEIM	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.1111
p.E712D	DO7828	COAD	ICGC	RRKRLEEIM	DEG_APCC_DBOX_1	708:716	Mutation altering degron motif	0.6758
p.K720N	DO8826	COAD	ICGC	RRKRLEEIM	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.2222
p.R714L	DO222501	COCA	ICGC	RRKRLEEIM	DEG_APCC_DBOX_1	708:716	Mutation altering degron motif	0.8428
p.E726D	DO222842	COCA	ICGC	RRKRLEEIM	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.0556
p.T298M	DO233210	GACA	ICGC	LMTPTLS	DEG_SCF_FBW7_1	300:306	Mutation rewiring degron network	0.2778
p.G290C	DO229028	LICA	ICGC	LMTPTLS	DEG_SCF_FBW7_1	300:306	Mutation blocking phosphorylation signal	0.5
p.G300S	DO220886	MELA	ICGC	LMTPTLS	DEG_SCF_FBW7_1	300:306	Mutation altering degron motif	0.6993
p.A302T	DO220900	MELA	ICGC	LMTPTLS	DEG_SCF_FBW7_1	300:306	Mutation altering degron motif	0.7139
p.P45L	DO220900	MELA	ICGC	VPDTPPDT	DEG_SCF_FBW7_1	44:51	Mutation altering degron motif	0.6471
p.N701K	DO50655	OV	ICGC	RRKRLEEIM	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.1389
p.T302K	DO231249	THCA	ICGC	LMTPTLS	DEG_SCF_FBW7_1	300:306	Mutation altering degron motif	0.8417
p.R314G	DO219786	UCEC	ICGC	LMTPTLS	DEG_SCF_FBW7_1	300:306	Mutation rewiring degron network	0.1111
p.Q706H	SIDM01307	Colorectal Carcinoma	GDSC	RRKRLEEIM	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.2778
p.T59I	SIDM00433	T-Lymphoblastic Leukemia	GDSC	VPDTPPDT	DEG_SCF_FBW7_1	44:51	Mutation rewiring degron network	0.1111
p.T59I	ACH-000795	Leukemia	CCLE	VPDTPPDT	DEG_SCF_FBW7_1	44:51	Mutation rewiring degron network	0.1111
p.T59I	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	VPDTPPDT	DEG_SCF_FBW7_1	44:51	Mutation rewiring degron network	0.1111
p.R720L	SIDM00572	Gastric Carcinoma	GDSC	RRKRLEEIM	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.2222
p.R720L	ACH-000911	Gastric Cancer	CCLE	RRKRLEEIM	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.2222
p.R720L	NUGC-3	stomach	COSMIC	RRKRLEEIM	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.2222
p.R310Q	SIDM00530	Esophageal Carcinoma	GDSC	LMTPTLS	DEG_SCF_FBW7_1	300:306	Mutation rewiring degron network	0.2222
p.R310Q	ACH-001544	Esophageal Cancer	CCLE	LMTPTLS	DEG_SCF_FBW7_1	300:306	Mutation rewiring degron network	0.2222
p.R310Q	KYAE-1	oesophagus	COSMIC	LMTPTLS	DEG_SCF_FBW7_1	300:306	Mutation rewiring degron network	0.2222
p.R705W	SIDM00121	T-Lymphoblastic Leukemia	GDSC	RRKRLEEIM	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.25
p.A821V	SIDM00793	Burkitt's Lymphoma	GDSC	LLPFAE	LIG_APCC_ABBA_1	817:822	Mutation altering degron motif	0.5825
p.R299H	SIDM00451	T-Lymphoblastic Leukemia	GDSC	LMTPTLS	DEG_SCF_FBW7_1	300:306	Mutation rewiring degron network	0.3056
p.R299H	ACH-000937	Leukemia	CCLE	LMTPTLS	DEG_SCF_FBW7_1	300:306	Mutation rewiring degron network	0.3056
p.R299H	PF-382	haematopoietic and lymphoid tissue	COSMIC	LMTPTLS	DEG_SCF_FBW7_1	300:306	Mutation rewiring degron network	0.3056
p.E824K	SIDM01503	Small Cell Lung Carcinoma	GDSC	LLPFAE	LIG_APCC_ABBA_1	817:822	Mutation rewiring degron network	0.2778
p.E824K	ACH-000844	Lung Cancer	CCLE	LLPFAE	LIG_APCC_ABBA_1	817:822	Mutation rewiring degron network	0.2778
p.R711H	SIDM01612	Endometrial Carcinoma	GDSC	RRKRLEEIM	DEG_APCC_DBOX_1	708:716	Mutation altering degron motif	0.7133
p.A314T	SIDM01664	Prostate Carcinoma	GDSC	LMTPTLS	DEG_SCF_FBW7_1	300:306	Mutation rewiring degron network	0.1111
p.A314T	ACH-000952	Prostate Cancer	CCLE	LMTPTLS	DEG_SCF_FBW7_1	300:306	Mutation rewiring degron network	0.1111
p.E707D	ACH-000997	Colon/Colorectal Cancer	CCLE	RRKRLEEIM	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.3056
p.E707D	ACH-001061	Colon/Colorectal Cancer	CCLE	RRKRLEEIM	DEG_APCC_DBOX_1	708:716	Mutation rewiring degron network	0.3056
p.S61F	ACH-001407	Bladder Cancer	CCLE	VPDTPPDT	DEG_SCF_FBW7_1	44:51	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAP7D1

UniProt ID: Q3KQU3

Entrez ID: 55700

Protein name: MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAP7D1 in