DegronMD

Uniprot ID: Q3KQU3

Source protein: MAP7 domain-containing protein 1

Source gene: MAP7D1

Class: DEG_APCC_DBOX_1

Location: 708:716

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.833

ASA_SCORE: 120.9111

COIL: 0.174

CONS_SCORE: 0.5142

DSS_SCORE: 0.5517

HELIX: 0.8281

FCONS_SCORE: 1.1012

RIG_SCORE: 0.7169

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A700T	DO49095	COAD	ICGC	RRKRLEEIM	DEG_APCC_DBOX_1	0.1111
p.A700T	DO233651	GACA	ICGC	RRKRLEEIM	DEG_APCC_DBOX_1	0.1111
p.A700T	DO41199	UCEC	ICGC	RRKRLEEIM	DEG_APCC_DBOX_1	0.1111
p.E712D	DO7828	COAD	ICGC	RRKRLEEIM	DEG_APCC_DBOX_1	0.6758
p.K720N	DO8826	COAD	ICGC	RRKRLEEIM	DEG_APCC_DBOX_1	0.2222
p.R714L	DO222501	COCA	ICGC	RRKRLEEIM	DEG_APCC_DBOX_1	0.8428
p.E726D	DO222842	COCA	ICGC	RRKRLEEIM	DEG_APCC_DBOX_1	0.0556
p.N701K	DO50655	OV	ICGC	RRKRLEEIM	DEG_APCC_DBOX_1	0.1389
p.Q706H	SIDM01307	Colorectal Carcinoma	GDSC	RRKRLEEIM	DEG_APCC_DBOX_1	0.2778
p.R720L	SIDM00572	Gastric Carcinoma	GDSC	RRKRLEEIM	DEG_APCC_DBOX_1	0.2222
p.R720L	ACH-000911	Gastric Cancer	CCLE	RRKRLEEIM	DEG_APCC_DBOX_1	0.2222
p.R720L	NUGC-3	stomach	COSMIC	RRKRLEEIM	DEG_APCC_DBOX_1	0.2222
p.R705W	SIDM00121	T-Lymphoblastic Leukemia	GDSC	RRKRLEEIM	DEG_APCC_DBOX_1	0.25
p.R711H	SIDM01612	Endometrial Carcinoma	GDSC	RRKRLEEIM	DEG_APCC_DBOX_1	0.7133
p.E707D	ACH-000997	Colon/Colorectal Cancer	CCLE	RRKRLEEIM	DEG_APCC_DBOX_1	0.3056
p.E707D	ACH-001061	Colon/Colorectal Cancer	CCLE	RRKRLEEIM	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3KQU3	MAP7 domain-containing protein 1	DEG_APCC_DBOX_1	708:716	RRKRLEEIM	APC,CDC20,FZR1	0.833	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons