DegronMD

Uniprot ID: Q3KQU3

Source protein: MAP7 domain-containing protein 1

Source gene: MAP7D1

Class: DEG_SCF_FBW7_1

Location: 44:51

E3 ligase: FBXW7

DEGRON score: 0.9941

ASA_SCORE: 100.25

COIL: 0.9773

CONS_SCORE: 0.3156

DSS_SCORE: 0.8245

HELIX: 0.0094

FCONS_SCORE: 1.1086

RIG_SCORE: 0.5421

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D46H	TCGA-06-1802	GBM	TCGA	VPDTPPDT	DEG_SCF_FBW7_1	0.6577
p.D46H	DO12100	GBM	ICGC	VPDTPPDT	DEG_SCF_FBW7_1	0.6577
p.M55I	TCGA-BT-A20O	BLCA	TCGA	VPDTPPDT	DEG_SCF_FBW7_1	0.2222
p.M55I	DO460	BLCA	ICGC	VPDTPPDT	DEG_SCF_FBW7_1	0.2222
p.P35L	TCGA-CJ-4637	KIRC	TCGA	VPDTPPDT	DEG_SCF_FBW7_1	0.0833
p.P35L	DO16495	KIRC	ICGC	VPDTPPDT	DEG_SCF_FBW7_1	0.0833
p.P48A	TCGA-WK-A8XQ	SARC	TCGA	VPDTPPDT	DEG_SCF_FBW7_1	0.7503
p.P48A	DO220295	SARC	ICGC	VPDTPPDT	DEG_SCF_FBW7_1	0.7503
p.P45L	DO220900	MELA	ICGC	VPDTPPDT	DEG_SCF_FBW7_1	0.6471
p.T59I	SIDM00433	T-Lymphoblastic Leukemia	GDSC	VPDTPPDT	DEG_SCF_FBW7_1	0.1111
p.T59I	ACH-000795	Leukemia	CCLE	VPDTPPDT	DEG_SCF_FBW7_1	0.1111
p.T59I	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	VPDTPPDT	DEG_SCF_FBW7_1	0.1111
p.S61F	ACH-001407	Bladder Cancer	CCLE	VPDTPPDT	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3KQU3	MAP7 domain-containing protein 1	DEG_SCF_FBW7_1	44:51	VPDTPPDT	FBXW7	0.9941	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons