DegronMD

Uniprot ID: Q3KQU3

Source protein: MAP7 domain-containing protein 1

Source gene: MAP7D1

Class: DEG_SCF_FBW7_1

Location: 300:306

E3 ligase: FBXW7

DEGRON score: 0.669

ASA_SCORE: 88.5143

COIL: 0.7757

CONS_SCORE: 0.7235

DSS_SCORE: 0.2608

HELIX: 0.1961

FCONS_SCORE: 1.0732

RIG_SCORE: 0.8077

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V297L	TCGA-A3-A8OU	KIRC	TCGA	LMTPTLS	DEG_SCF_FBW7_1	0.25
p.V297L	DO219231	KIRC	ICGC	LMTPTLS	DEG_SCF_FBW7_1	0.25
p.V297L	DO229041	LICA	ICGC	LMTPTLS	DEG_SCF_FBW7_1	0.25
p.E293Q	TCGA-DK-A3WW	BLCA	TCGA	LMTPTLS	DEG_SCF_FBW7_1	0.1389
p.A291T	TCGA-EO-A22U	UCEC	TCGA	LMTPTLS	DEG_SCF_FBW7_1	0.0833
p.W292C	TCGA-ER-A19B	SKCM	TCGA	LMTPTLS	DEG_SCF_FBW7_1	0.1111
p.T302M	TCGA-FR-A726	SKCM	TCGA	LMTPTLS	DEG_SCF_FBW7_1	0.8534
p.T302M	SIDM00282	Colorectal Carcinoma	GDSC	LMTPTLS	DEG_SCF_FBW7_1	0.8534
p.T302M	ACH-000998	Colon/Colorectal Cancer	CCLE	LMTPTLS	DEG_SCF_FBW7_1	0.8534
p.T302M	CW-2	large_intestine	COSMIC	LMTPTLS	DEG_SCF_FBW7_1	0.8534
p.D298N	TCGA-V1-A9OY	PRAD	TCGA	LMTPTLS	DEG_SCF_FBW7_1	0.2778
p.D298N	DO219389	PRAD	ICGC	LMTPTLS	DEG_SCF_FBW7_1	0.2778
p.R299C	TCGA-WS-AB45	COAD	TCGA	LMTPTLS	DEG_SCF_FBW7_1	0.3056
p.R314H	DO229363	BTCA	ICGC	LMTPTLS	DEG_SCF_FBW7_1	0.1111
p.R314H	DO230309	COCA	ICGC	LMTPTLS	DEG_SCF_FBW7_1	0.1111
p.T298M	DO233210	GACA	ICGC	LMTPTLS	DEG_SCF_FBW7_1	0.2778
p.G290C	DO229028	LICA	ICGC	LMTPTLS	DEG_SCF_FBW7_1	0.5
p.G300S	DO220886	MELA	ICGC	LMTPTLS	DEG_SCF_FBW7_1	0.6993
p.A302T	DO220900	MELA	ICGC	LMTPTLS	DEG_SCF_FBW7_1	0.7139
p.T302K	DO231249	THCA	ICGC	LMTPTLS	DEG_SCF_FBW7_1	0.8417
p.R314G	DO219786	UCEC	ICGC	LMTPTLS	DEG_SCF_FBW7_1	0.1111
p.R310Q	SIDM00530	Esophageal Carcinoma	GDSC	LMTPTLS	DEG_SCF_FBW7_1	0.2222
p.R310Q	ACH-001544	Esophageal Cancer	CCLE	LMTPTLS	DEG_SCF_FBW7_1	0.2222
p.R310Q	KYAE-1	oesophagus	COSMIC	LMTPTLS	DEG_SCF_FBW7_1	0.2222
p.R299H	SIDM00451	T-Lymphoblastic Leukemia	GDSC	LMTPTLS	DEG_SCF_FBW7_1	0.3056
p.R299H	ACH-000937	Leukemia	CCLE	LMTPTLS	DEG_SCF_FBW7_1	0.3056
p.R299H	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	LMTPTLS	DEG_SCF_FBW7_1	0.3056
p.A314T	SIDM01664	Prostate Carcinoma	GDSC	LMTPTLS	DEG_SCF_FBW7_1	0.1111
p.A314T	ACH-000952	Prostate Cancer	CCLE	LMTPTLS	DEG_SCF_FBW7_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LMTPTLS

Degron related mutations and impact score

Drug responses associated with MAP7D1 mutations

All proteins holding degron of LMTPTLS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3KQU3	MAP7 domain-containing protein 1	DEG_SCF_FBW7_1	300:306	LMTPTLS	FBXW7	0.669	More...