DegronMD

Uniprot ID: O43242

Source protein: 26S proteasome non-ATPase regulatory subunit 3

Source gene: PSMD3

Class: LIG_APCC_ABBA_1

Location: 131:136

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9345

ASA_SCORE: 53.2167

COIL: 0.544

CONS_SCORE: 0.4108

DSS_SCORE: 0.3548

HELIX: 0.379

FCONS_SCORE: 1.2688

RIG_SCORE: 0.8766

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E137D	TCGA-A5-A0G2	UCEC	TCGA	LLPFLE	LIG_APCC_ABBA_1	0.3056
p.R128Q	TCGA-AX-A2HC	UCEC	TCGA	LLPFLE	LIG_APCC_ABBA_1	0.25
p.R128Q	TCGA-XF-A8HD	BLCA	TCGA	LLPFLE	LIG_APCC_ABBA_1	0.25
p.F134Y	DO233245	GACA	ICGC	LLPFLE	LIG_APCC_ABBA_1	0.6417
p.L132F	DO222662	MELA	ICGC	LLPFLE	LIG_APCC_ABBA_1	0.587
p.D140N	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LLPFLE	LIG_APCC_ABBA_1	0.2222
p.D140N	ACH-000995	Leukemia	CCLE	LLPFLE	LIG_APCC_ABBA_1	0.2222
p.D140N	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	LLPFLE	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43242	26S proteasome non-ATPase regulatory subunit 3	LIG_APCC_ABBA_1	131:136	LLPFLE	APC,CDC20,FZR1	0.9345	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons