DegronMD

Uniprot ID: Q8TBZ3

Source protein: WD repeat-containing protein 20

Source gene: WDR20

Class: LIG_APCC_ABBA_1

Location: 26:31

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7158

ASA_SCORE: 68.8167

COIL: 0.5708

CONS_SCORE: 0.4823

DSS_SCORE: 0.4871

HELIX: 0.1062

FCONS_SCORE: 0.9417

RIG_SCORE: 0.7578

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P39S	TCGA-BG-A222	UCEC	TCGA	LLPHSE	LIG_APCC_ABBA_1	0.1111
p.P39S	DO42977	UCEC	ICGC	LLPHSE	LIG_APCC_ABBA_1	0.1111
p.P28Q	SIDM00845	Burkitt's Lymphoma	GDSC	LLPHSE	LIG_APCC_ABBA_1	0.7035
p.P28Q	SIDM00461	Acute Myeloid Leukemia	GDSC	LLPHSE	LIG_APCC_ABBA_1	0.7035
p.P28Q	SIDM00946	T-Lymphoblastic Leukemia	GDSC	LLPHSE	LIG_APCC_ABBA_1	0.7035
p.P28Q	SIDM01519	Head and Neck Carcinoma	GDSC	LLPHSE	LIG_APCC_ABBA_1	0.7035
p.P28Q	ACH-000786	Lymphoma	CCLE	LLPHSE	LIG_APCC_ABBA_1	0.7035
p.P28Q	ACH-000981	Leukemia	CCLE	LLPHSE	LIG_APCC_ABBA_1	0.7035
p.P28Q	ACH-000992	Head and Neck Cancer	CCLE	LLPHSE	LIG_APCC_ABBA_1	0.7035
p.P28Q	ACH-001067	Brain Cancer	CCLE	LLPHSE	LIG_APCC_ABBA_1	0.7035
p.P28Q	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	LLPHSE	LIG_APCC_ABBA_1	0.7035
p.P28Q	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	LLPHSE	LIG_APCC_ABBA_1	0.7035
p.P28Q	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	LLPHSE	LIG_APCC_ABBA_1	0.7035
p.P28S	SIDM00217	Colorectal Carcinoma	GDSC	LLPHSE	LIG_APCC_ABBA_1	0.6752
p.P28S	SNU-1040	large_intestine	COSMIC	LLPHSE	LIG_APCC_ABBA_1	0.6752
p.V38A	ACH-000938	Leukemia	CCLE	LLPHSE	LIG_APCC_ABBA_1	0.1389
p.V38A	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	LLPHSE	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TBZ3	WD repeat-containing protein 20	LIG_APCC_ABBA_1	26:31	LLPHSE	APC,CDC20,FZR1	0.7158	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons