DegronMD - Q8TBZ3(WDR20)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E416D	TCGA-19-5956	GBM	TCGA	VTTPGNS	DEG_SCF_FBW7_1	418:424	Mutation rewiring degron network	0.2778
p.T430A	TCGA-AX-A1CE	UCEC	TCGA	VTTPGNS	DEG_SCF_FBW7_1	418:424	Mutation rewiring degron network	0.1667
p.L419I	TCGA-B9-A44B	KIRP	TCGA	VTTPGNS	DEG_SCF_FBW7_1	418:424	Mutation altering degron motif	0.7174
p.P39S	TCGA-BG-A222	UCEC	TCGA	LLPHSE	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.1111
p.P39S	DO42977	UCEC	ICGC	LLPHSE	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.1111
p.E414K	DO1285	BRCA	ICGC	VTTPGNS	DEG_SCF_FBW7_1	418:424	Mutation rewiring degron network	0.2222
p.K418R	DO228627	GACA	ICGC	VTTPGNS	DEG_SCF_FBW7_1	418:424	Mutation altering degron motif	0.7237
p.N11S	DO233109	GACA	ICGC	TREGLYKLL	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.1111
p.S427C	DO52079	HNSC	ICGC	VTTPGNS	DEG_SCF_FBW7_1	418:424	Mutation rewiring degron network	0.25
p.M10I	DO229026	LICA	ICGC	TREGLYKLL	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.0833
p.K418N	DO229032	LICA	ICGC	VTTPGNS	DEG_SCF_FBW7_1	418:424	Mutation altering degron motif	0.6918
p.S427F	DO222396	MELA	ICGC	VTTPGNS	DEG_SCF_FBW7_1	418:424	Mutation rewiring degron network	0.25
p.D432N	DO41175	UCEC	ICGC	VTTPGNS	DEG_SCF_FBW7_1	418:424	Mutation blocking phosphorylation signal	0.5556
p.P28Q	SIDM00845	Burkitt's Lymphoma	GDSC	LLPHSE	LIG_APCC_ABBA_1	26:31	Mutation altering degron motif	0.7035
p.P28Q	SIDM00461	Acute Myeloid Leukemia	GDSC	LLPHSE	LIG_APCC_ABBA_1	26:31	Mutation altering degron motif	0.7035
p.P28Q	SIDM00946	T-Lymphoblastic Leukemia	GDSC	LLPHSE	LIG_APCC_ABBA_1	26:31	Mutation altering degron motif	0.7035
p.P28Q	SIDM01519	Head and Neck Carcinoma	GDSC	LLPHSE	LIG_APCC_ABBA_1	26:31	Mutation altering degron motif	0.7035
p.P28Q	ACH-000786	Lymphoma	CCLE	LLPHSE	LIG_APCC_ABBA_1	26:31	Mutation altering degron motif	0.7035
p.P28Q	ACH-000981	Leukemia	CCLE	LLPHSE	LIG_APCC_ABBA_1	26:31	Mutation altering degron motif	0.7035
p.P28Q	ACH-000992	Head and Neck Cancer	CCLE	LLPHSE	LIG_APCC_ABBA_1	26:31	Mutation altering degron motif	0.7035
p.P28Q	ACH-001067	Brain Cancer	CCLE	LLPHSE	LIG_APCC_ABBA_1	26:31	Mutation altering degron motif	0.7035
p.P28Q	DND-41	haematopoietic and lymphoid tissue	COSMIC	LLPHSE	LIG_APCC_ABBA_1	26:31	Mutation altering degron motif	0.7035
p.P28Q	Daudi	haematopoietic and lymphoid tissue	COSMIC	LLPHSE	LIG_APCC_ABBA_1	26:31	Mutation altering degron motif	0.7035
p.P28Q	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	LLPHSE	LIG_APCC_ABBA_1	26:31	Mutation altering degron motif	0.7035
p.P28S	SIDM00217	Colorectal Carcinoma	GDSC	LLPHSE	LIG_APCC_ABBA_1	26:31	Mutation altering degron motif	0.6752
p.P28S	SNU-1040	large intestine	COSMIC	LLPHSE	LIG_APCC_ABBA_1	26:31	Mutation altering degron motif	0.6752
p.P409S	ACH-000200	Brain Cancer	CCLE	VTTPGNS	DEG_SCF_FBW7_1	418:424	Mutation rewiring degron network	0.0833
p.P409S	NMC-G1	central nervous system	COSMIC	VTTPGNS	DEG_SCF_FBW7_1	418:424	Mutation rewiring degron network	0.0833
p.V38A	ACH-000938	Leukemia	CCLE	LLPHSE	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.1389
p.V38A	NALM-6	haematopoietic and lymphoid tissue	COSMIC	LLPHSE	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.1389
p.S431N	NCI-H1105	lung	COSMIC	VTTPGNS	DEG_SCF_FBW7_1	418:424	Mutation rewiring degron network	0.1389
p.D432G	CHL-1	skin	COSMIC	VTTPGNS	DEG_SCF_FBW7_1	418:424	Mutation blocking phosphorylation signal	0.5556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WDR20

UniProt ID: Q8TBZ3

Entrez ID: 91833

Protein name: WD repeat-containing protein 20 (Protein DMR)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WDR20 in