DegronMD

Uniprot ID: Q8TBZ3

Source protein: WD repeat-containing protein 20

Source gene: WDR20

Class: DEG_SCF_FBW7_1

Location: 418:424

E3 ligase: FBXW7

DEGRON score: 0.9172

ASA_SCORE: 64.5286

COIL: 0.8231

CONS_SCORE: 0.3638

DSS_SCORE: 0.7277

HELIX: 0.0294

FCONS_SCORE: 0.9509

RIG_SCORE: 0.566

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E416D	TCGA-19-5956	GBM	TCGA	VTTPGNS	DEG_SCF_FBW7_1	0.2778
p.T430A	TCGA-AX-A1CE	UCEC	TCGA	VTTPGNS	DEG_SCF_FBW7_1	0.1667
p.L419I	TCGA-B9-A44B	KIRP	TCGA	VTTPGNS	DEG_SCF_FBW7_1	0.7174
p.E414K	DO1285	BRCA	ICGC	VTTPGNS	DEG_SCF_FBW7_1	0.2222
p.K418R	DO228627	GACA	ICGC	VTTPGNS	DEG_SCF_FBW7_1	0.7237
p.S427C	DO52079	HNSC	ICGC	VTTPGNS	DEG_SCF_FBW7_1	0.25
p.K418N	DO229032	LICA	ICGC	VTTPGNS	DEG_SCF_FBW7_1	0.6918
p.S427F	DO222396	MELA	ICGC	VTTPGNS	DEG_SCF_FBW7_1	0.25
p.D432N	DO41175	UCEC	ICGC	VTTPGNS	DEG_SCF_FBW7_1	0.5556
p.P409S	ACH-000200	Brain Cancer	CCLE	VTTPGNS	DEG_SCF_FBW7_1	0.0833
p.P409S	NMC-G1	central_nervous_system	COSMIC	VTTPGNS	DEG_SCF_FBW7_1	0.0833
p.S431N	NCI-H1105	lung	COSMIC	VTTPGNS	DEG_SCF_FBW7_1	0.1389
p.D432G	CHL-1	skin	COSMIC	VTTPGNS	DEG_SCF_FBW7_1	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TBZ3	WD repeat-containing protein 20	DEG_SCF_FBW7_1	418:424	VTTPGNS	FBXW7	0.9172	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons