DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
TREGLYKLL
Uniprot ID:
Q8TBZ3
Source protein:
WD repeat-containing protein 20
Source gene:
WDR20
Class:
DEG_APCC_DBOX_1
Location:
19:27
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7956
ASA_SCORE:
57.7667
COIL:
0.4003
CONS_SCORE:
0.5716
DSS_SCORE:
0.4718
HELIX:
0.0126
FCONS_SCORE:
1.268
RIG_SCORE:
0.7881
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.N11S
DO233109
GACA
ICGC
TREGLYKLL
DEG_APCC_DBOX_1
0.1111
p.M10I
DO229026
LICA
ICGC
TREGLYKLL
DEG_APCC_DBOX_1
0.0833
Drug responses associated with WDR20 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of TREGLYKLL
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8TBZ3
WD repeat-containing protein 20
DEG_APCC_DBOX_1
19:27
TREGLYKLL
APC,CDC20,FZR1
0.7956
More...