DegronMD

Uniprot ID: O43149

Source protein: Zinc finger ZZ-type and EF-hand domain-containing protein 1

Source gene: ZZEF1

Class: DEG_SCF_FBW7_2

Location: 63:70

E3 ligase: FBXW7

DEGRON score: 0.5921

ASA_SCORE: 74.5125

COIL: 0.8044

CONS_SCORE: 0.4381

DSS_SCORE: 0.2988

HELIX: 0.1805

FCONS_SCORE: 0.7486

RIG_SCORE: 0.7266

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G78C	TCGA-DK-A2I1	BLCA	TCGA	LLPTPPCE	DEG_SCF_FBW7_2	0.1111
p.G78C	DO444	BLCA	ICGC	LLPTPPCE	DEG_SCF_FBW7_2	0.1111
p.R77C	TCGA-DK-A3IT	BLCA	TCGA	LLPTPPCE	DEG_SCF_FBW7_2	0.1389
p.R77C	DO779	BLCA	ICGC	LLPTPPCE	DEG_SCF_FBW7_2	0.1389
p.R77C	ACH-000777	Esophageal Cancer	CCLE	LLPTPPCE	DEG_SCF_FBW7_2	0.1389
p.A59V	TCGA-FW-A3TV	SKCM	TCGA	LLPTPPCE	DEG_SCF_FBW7_2	0.2222
p.A59V	DO38159	SKCM	ICGC	LLPTPPCE	DEG_SCF_FBW7_2	0.2222
p.R55S	ACH-001128	Rhabdoid	CCLE	LLPTPPCE	DEG_SCF_FBW7_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43149	Zinc finger ZZ-type and EF-hand domain-containing protein 1	DEG_SCF_FBW7_2	63:70	LLPTPPCE	FBXW7	0.5921	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons