DegronMD - O43149(ZZEF1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K1496R	TCGA-28-2506	GBM	TCGA	LPAADVSPA	DEG_SIAH_1	1503:1511	Mutation substituting flanking lysine	0.25
p.K1496R	DO11585	GBM	ICGC	LPAADVSPA	DEG_SIAH_1	1503:1511	Mutation substituting flanking lysine	0.25
p.R1525P	TCGA-56-8083	LUSC	TCGA	TRGRLRLLS	DEG_APCC_DBOX_1	1529:1537	Mutation rewiring degron network	0.2222
p.R1525P	DO223723	LUSC	ICGC	TRGRLRLLS	DEG_APCC_DBOX_1	1529:1537	Mutation rewiring degron network	0.2222
p.S1499F	TCGA-66-2756	LUSC	TCGA	LPAADVSPA	DEG_SIAH_1	1503:1511	Mutation blocking phosphorylation signal	0.6667
p.S1499F	DO27128	LUSC	ICGC	LPAADVSPA	DEG_SIAH_1	1503:1511	Mutation blocking phosphorylation signal	0.6667
p.R1534W	TCGA-AP-A1DK	UCEC	TCGA	TRGRLRLLS	DEG_APCC_DBOX_1	1529:1537	Mutation altering degron motif	0.7523
p.R1534W	DO42033	UCEC	ICGC	TRGRLRLLS	DEG_APCC_DBOX_1	1529:1537	Mutation altering degron motif	0.7523
p.R1534W	SIDM00491	Thyroid Gland Carcinoma	GDSC	TRGRLRLLS	DEG_APCC_DBOX_1	1529:1537	Mutation altering degron motif	0.7523
p.R1534W	SIDM00999	Bladder Carcinoma	GDSC	TRGRLRLLS	DEG_APCC_DBOX_1	1529:1537	Mutation altering degron motif	0.7523
p.R1534W	ACH-000973	Bladder Cancer	CCLE	TRGRLRLLS	DEG_APCC_DBOX_1	1529:1537	Mutation altering degron motif	0.7523
p.R1534W	ASH-3	thyroid	COSMIC	TRGRLRLLS	DEG_APCC_DBOX_1	1529:1537	Mutation altering degron motif	0.7523
p.R1534W	639-V	urinary tract	COSMIC	TRGRLRLLS	DEG_APCC_DBOX_1	1529:1537	Mutation altering degron motif	0.7523
p.A1513T	TCGA-BR-8078	STAD	TCGA	LPAADVSPA	DEG_SIAH_1	1503:1511	Mutation rewiring degron network	0.2778
p.A1513T	DO38288	STAD	ICGC	LPAADVSPA	DEG_SIAH_1	1503:1511	Mutation rewiring degron network	0.2778
p.S2085F	TCGA-CK-4951	COAD	TCGA	VTPSPE	DEG_SCF_FBW7_2	2073:2078	Mutation rewiring degron network	0.1389
p.S2085F	DO10582	COAD	ICGC	VTPSPE	DEG_SCF_FBW7_2	2073:2078	Mutation rewiring degron network	0.1389
p.E1514D	TCGA-D9-A6EC	SKCM	TCGA	LPAADVSPA	DEG_SIAH_1	1503:1511	Mutation rewiring degron network	0.25
p.E1514D	DO50291	SKCM	ICGC	LPAADVSPA	DEG_SIAH_1	1503:1511	Mutation rewiring degron network	0.25
p.A1513V	TCGA-DF-A2KU	UCEC	TCGA	LPAADVSPA	DEG_SIAH_1	1503:1511	Mutation rewiring degron network	0.2778
p.A1513V	DO223286	UCEC	ICGC	LPAADVSPA	DEG_SIAH_1	1503:1511	Mutation rewiring degron network	0.2778
p.G78C	TCGA-DK-A2I1	BLCA	TCGA	LLPTPPCE	DEG_SCF_FBW7_2	63:70	Mutation rewiring degron network	0.1111
p.G78C	DO444	BLCA	ICGC	LLPTPPCE	DEG_SCF_FBW7_2	63:70	Mutation rewiring degron network	0.1111
p.R77C	TCGA-DK-A3IT	BLCA	TCGA	LLPTPPCE	DEG_SCF_FBW7_2	63:70	Mutation rewiring degron network	0.1389
p.R77C	DO779	BLCA	ICGC	LLPTPPCE	DEG_SCF_FBW7_2	63:70	Mutation rewiring degron network	0.1389
p.R77C	ACH-000777	Esophageal Cancer	CCLE	LLPTPPCE	DEG_SCF_FBW7_2	63:70	Mutation rewiring degron network	0.1389
p.P1548L	TCGA-EE-A2GN	SKCM	TCGA	SMEEARLVPTV	DEG_COP1_1	1540:1550	Mutation altering degron motif	0.7582
p.P1548L	DO37896	SKCM	ICGC	SMEEARLVPTV	DEG_COP1_1	1540:1550	Mutation altering degron motif	0.7582
p.G1531W	TCGA-EE-A2MD	SKCM	TCGA	TRGRLRLLS	DEG_APCC_DBOX_1	1529:1537	Mutation altering degron motif	0.6714
p.G1531W	DO37851	SKCM	ICGC	TRGRLRLLS	DEG_APCC_DBOX_1	1529:1537	Mutation altering degron motif	0.6714
p.R1525Q	TCGA-EY-A1GU	UCEC	TCGA	TRGRLRLLS	DEG_APCC_DBOX_1	1529:1537	Mutation rewiring degron network	0.2222
p.R1525Q	DO41518	UCEC	ICGC	TRGRLRLLS	DEG_APCC_DBOX_1	1529:1537	Mutation rewiring degron network	0.2222
p.A59V	TCGA-FW-A3TV	SKCM	TCGA	LLPTPPCE	DEG_SCF_FBW7_2	63:70	Mutation rewiring degron network	0.2222
p.A59V	DO38159	SKCM	ICGC	LLPTPPCE	DEG_SCF_FBW7_2	63:70	Mutation rewiring degron network	0.2222
p.P2067S	DO222454	BTCA	ICGC	VTPSPE	DEG_SCF_FBW7_2	2073:2078	Mutation rewiring degron network	0.1667
p.T2074N	DO228952	LICA	ICGC	VTPSPE	DEG_SCF_FBW7_2	2073:2078	Mutation altering degron motif	0.8166
p.P1498Q	DO229028	LICA	ICGC	LPAADVSPA	DEG_SIAH_1	1503:1511	Mutation rewiring degron network	0.1944
p.S1499P	DO220841	MELA	ICGC	LPAADVSPA	DEG_SIAH_1	1503:1511	Mutation blocking phosphorylation signal	0.6667
p.E2070K	DO229462	SKCA	ICGC	VTPSPE	DEG_SCF_FBW7_2	2073:2078	Mutation rewiring degron network	0.25
p.M1541T	SIDM00572	Gastric Carcinoma	GDSC	SMEEARLVPTV	DEG_COP1_1	1540:1550	Mutation altering degron motif	0.6312
p.M1541T	ACH-000911	Gastric Cancer	CCLE	SMEEARLVPTV	DEG_COP1_1	1540:1550	Mutation altering degron motif	0.6312
p.M1541T	NUGC-3	stomach	COSMIC	SMEEARLVPTV	DEG_COP1_1	1540:1550	Mutation altering degron motif	0.6312
p.L1536F	SIDM00319	Melanoma	GDSC	TRGRLRLLS	DEG_APCC_DBOX_1	1529:1537	Mutation altering degron motif	0.6981
p.L1536F	SIDM00269	Ewing's Sarcoma	GDSC	TRGRLRLLS	DEG_APCC_DBOX_1	1529:1537	Mutation altering degron motif	0.6981
p.L1536F	ACH-001704	Skin Cancer	CCLE	TRGRLRLLS	DEG_APCC_DBOX_1	1529:1537	Mutation altering degron motif	0.6981
p.L1536F	ACH-002108	Bone Cancer	CCLE	TRGRLRLLS	DEG_APCC_DBOX_1	1529:1537	Mutation altering degron motif	0.6981
p.L1536F	VMRC-MELG	skin	COSMIC	TRGRLRLLS	DEG_APCC_DBOX_1	1529:1537	Mutation altering degron motif	0.6981
p.L1536F	ES7	bone	COSMIC	TRGRLRLLS	DEG_APCC_DBOX_1	1529:1537	Mutation altering degron motif	0.6981
p.V2073D	SIDM00789	Colorectal Carcinoma	GDSC	VTPSPE	DEG_SCF_FBW7_2	2073:2078	Mutation altering degron motif	0.7785
p.V2073D	ACH-000997	Colon/Colorectal Cancer	CCLE	VTPSPE	DEG_SCF_FBW7_2	2073:2078	Mutation altering degron motif	0.7785
p.V2073D	HCT-15	large intestine	COSMIC	VTPSPE	DEG_SCF_FBW7_2	2073:2078	Mutation altering degron motif	0.7785
p.T1549A	SIDM00217	Colorectal Carcinoma	GDSC	SMEEARLVPTV	DEG_COP1_1	1540:1550	Mutation altering degron motif	0.7139
p.T1549A	ACH-000999	Colon/Colorectal Cancer	CCLE	SMEEARLVPTV	DEG_COP1_1	1540:1550	Mutation altering degron motif	0.7139
p.T1549A	SNU-1040	large intestine	COSMIC	SMEEARLVPTV	DEG_COP1_1	1540:1550	Mutation altering degron motif	0.7139
p.R1530Q	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	TRGRLRLLS	DEG_APCC_DBOX_1	1529:1537	Mutation altering degron motif	0.7329
p.R1530Q	ACH-000726	Esophageal Cancer	CCLE	TRGRLRLLS	DEG_APCC_DBOX_1	1529:1537	Mutation altering degron motif	0.7329
p.R55S	ACH-001128	Rhabdoid	CCLE	LLPTPPCE	DEG_SCF_FBW7_2	63:70	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZZEF1

UniProt ID: O43149

Entrez ID: 23140

Protein name: Zinc finger ZZ-type and EF-hand domain-containing protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZZEF1 in