DegronMD

Uniprot ID: O43149

Source protein: Zinc finger ZZ-type and EF-hand domain-containing protein 1

Source gene: ZZEF1

Class: DEG_APCC_DBOX_1

Location: 1529:1537

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9734

ASA_SCORE: 76.6

COIL: 0.4478

CONS_SCORE: 0.3691

DSS_SCORE: 0.4453

HELIX: 0.491

FCONS_SCORE: 0.9992

RIG_SCORE: 0.7675

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1525P	TCGA-56-8083	LUSC	TCGA	TRGRLRLLS	DEG_APCC_DBOX_1	0.2222
p.R1525P	DO223723	LUSC	ICGC	TRGRLRLLS	DEG_APCC_DBOX_1	0.2222
p.R1534W	TCGA-AP-A1DK	UCEC	TCGA	TRGRLRLLS	DEG_APCC_DBOX_1	0.7523
p.R1534W	DO42033	UCEC	ICGC	TRGRLRLLS	DEG_APCC_DBOX_1	0.7523
p.R1534W	SIDM00491	Thyroid Gland Carcinoma	GDSC	TRGRLRLLS	DEG_APCC_DBOX_1	0.7523
p.R1534W	SIDM00999	Bladder Carcinoma	GDSC	TRGRLRLLS	DEG_APCC_DBOX_1	0.7523
p.R1534W	ACH-000973	Bladder Cancer	CCLE	TRGRLRLLS	DEG_APCC_DBOX_1	0.7523
p.R1534W	ASH-3	thyroid	COSMIC	TRGRLRLLS	DEG_APCC_DBOX_1	0.7523
p.R1534W	639-V	urinary_tract	COSMIC	TRGRLRLLS	DEG_APCC_DBOX_1	0.7523
p.G1531W	TCGA-EE-A2MD	SKCM	TCGA	TRGRLRLLS	DEG_APCC_DBOX_1	0.6714
p.G1531W	DO37851	SKCM	ICGC	TRGRLRLLS	DEG_APCC_DBOX_1	0.6714
p.R1525Q	TCGA-EY-A1GU	UCEC	TCGA	TRGRLRLLS	DEG_APCC_DBOX_1	0.2222
p.R1525Q	DO41518	UCEC	ICGC	TRGRLRLLS	DEG_APCC_DBOX_1	0.2222
p.L1536F	SIDM00319	Melanoma	GDSC	TRGRLRLLS	DEG_APCC_DBOX_1	0.6981
p.L1536F	SIDM00269	Ewing's Sarcoma	GDSC	TRGRLRLLS	DEG_APCC_DBOX_1	0.6981
p.L1536F	ACH-001704	Skin Cancer	CCLE	TRGRLRLLS	DEG_APCC_DBOX_1	0.6981
p.L1536F	ACH-002108	Bone Cancer	CCLE	TRGRLRLLS	DEG_APCC_DBOX_1	0.6981
p.L1536F	VMRC-MELG	skin	COSMIC	TRGRLRLLS	DEG_APCC_DBOX_1	0.6981
p.L1536F	ES7	bone	COSMIC	TRGRLRLLS	DEG_APCC_DBOX_1	0.6981
p.R1530Q	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	TRGRLRLLS	DEG_APCC_DBOX_1	0.7329
p.R1530Q	ACH-000726	Esophageal Cancer	CCLE	TRGRLRLLS	DEG_APCC_DBOX_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43149	Zinc finger ZZ-type and EF-hand domain-containing protein 1	DEG_APCC_DBOX_1	1529:1537	TRGRLRLLS	APC,CDC20,FZR1	0.9734	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons