DegronMD

Uniprot ID: O43149

Source protein: Zinc finger ZZ-type and EF-hand domain-containing protein 1

Source gene: ZZEF1

Class: DEG_SCF_FBW7_2

Location: 2073:2078

E3 ligase: FBXW7

DEGRON score: 0.8999

ASA_SCORE: 74.0833

COIL: 0.7218

CONS_SCORE: 0.3964

DSS_SCORE: 0.554

HELIX: 0.2455

FCONS_SCORE: 0.7894

RIG_SCORE: 0.6899

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2085F	TCGA-CK-4951	COAD	TCGA	VTPSPE	DEG_SCF_FBW7_2	0.1389
p.S2085F	DO10582	COAD	ICGC	VTPSPE	DEG_SCF_FBW7_2	0.1389
p.P2067S	DO222454	BTCA	ICGC	VTPSPE	DEG_SCF_FBW7_2	0.1667
p.T2074N	DO228952	LICA	ICGC	VTPSPE	DEG_SCF_FBW7_2	0.8166
p.E2070K	DO229462	SKCA	ICGC	VTPSPE	DEG_SCF_FBW7_2	0.25
p.V2073D	SIDM00789	Colorectal Carcinoma	GDSC	VTPSPE	DEG_SCF_FBW7_2	0.7785
p.V2073D	ACH-000997	Colon/Colorectal Cancer	CCLE	VTPSPE	DEG_SCF_FBW7_2	0.7785
p.V2073D	HCT-15	large_intestine	COSMIC	VTPSPE	DEG_SCF_FBW7_2	0.7785

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43149	Zinc finger ZZ-type and EF-hand domain-containing protein 1	DEG_SCF_FBW7_2	2073:2078	VTPSPE	FBXW7	0.8999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons