DegronMD

Uniprot ID: O43149

Source protein: Zinc finger ZZ-type and EF-hand domain-containing protein 1

Source gene: ZZEF1

Class: DEG_COP1_1

Location: 1540:1550

E3 ligase: COP1

DEGRON score: 0.7444

ASA_SCORE: 71.1182

COIL: 0.5314

CONS_SCORE: 0.4077

DSS_SCORE: 0.2653

HELIX: 0.4355

FCONS_SCORE: 0.961

RIG_SCORE: 0.7855

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1548L	TCGA-EE-A2GN	SKCM	TCGA	SMEEARLVPTV	DEG_COP1_1	0.7582
p.P1548L	DO37896	SKCM	ICGC	SMEEARLVPTV	DEG_COP1_1	0.7582
p.M1541T	SIDM00572	Gastric Carcinoma	GDSC	SMEEARLVPTV	DEG_COP1_1	0.6312
p.M1541T	ACH-000911	Gastric Cancer	CCLE	SMEEARLVPTV	DEG_COP1_1	0.6312
p.M1541T	NUGC-3	stomach	COSMIC	SMEEARLVPTV	DEG_COP1_1	0.6312
p.T1549A	SIDM00217	Colorectal Carcinoma	GDSC	SMEEARLVPTV	DEG_COP1_1	0.7139
p.T1549A	ACH-000999	Colon/Colorectal Cancer	CCLE	SMEEARLVPTV	DEG_COP1_1	0.7139
p.T1549A	SNU-1040	large_intestine	COSMIC	SMEEARLVPTV	DEG_COP1_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43149	Zinc finger ZZ-type and EF-hand domain-containing protein 1	DEG_COP1_1	1540:1550	SMEEARLVPTV	COP1	0.7444	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons