DegronMD

Uniprot ID: O43149

Source protein: Zinc finger ZZ-type and EF-hand domain-containing protein 1

Source gene: ZZEF1

Class: DEG_SIAH_1

Location: 1503:1511

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.7381

ASA_SCORE: 66.6556

COIL: 0.7512

CONS_SCORE: 0.2473

DSS_SCORE: 0.6979

HELIX: 0.1826

FCONS_SCORE: 0.8447

RIG_SCORE: 0.5899

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K1496R	TCGA-28-2506	GBM	TCGA	LPAADVSPA	DEG_SIAH_1	0.25
p.K1496R	DO11585	GBM	ICGC	LPAADVSPA	DEG_SIAH_1	0.25
p.S1499F	TCGA-66-2756	LUSC	TCGA	LPAADVSPA	DEG_SIAH_1	0.6667
p.S1499F	DO27128	LUSC	ICGC	LPAADVSPA	DEG_SIAH_1	0.6667
p.A1513T	TCGA-BR-8078	STAD	TCGA	LPAADVSPA	DEG_SIAH_1	0.2778
p.A1513T	DO38288	STAD	ICGC	LPAADVSPA	DEG_SIAH_1	0.2778
p.E1514D	TCGA-D9-A6EC	SKCM	TCGA	LPAADVSPA	DEG_SIAH_1	0.25
p.E1514D	DO50291	SKCM	ICGC	LPAADVSPA	DEG_SIAH_1	0.25
p.A1513V	TCGA-DF-A2KU	UCEC	TCGA	LPAADVSPA	DEG_SIAH_1	0.2778
p.A1513V	DO223286	UCEC	ICGC	LPAADVSPA	DEG_SIAH_1	0.2778
p.P1498Q	DO229028	LICA	ICGC	LPAADVSPA	DEG_SIAH_1	0.1944
p.S1499P	DO220841	MELA	ICGC	LPAADVSPA	DEG_SIAH_1	0.6667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43149	Zinc finger ZZ-type and EF-hand domain-containing protein 1	DEG_SIAH_1	1503:1511	LPAADVSPA	SIAH1,SIAH2,SIAH3	0.7381	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons