DegronMD

Uniprot ID: Q9BTV7

Source protein: CDK5 and ABL1 enzyme substrate 2

Source gene: CABLES2

Class: DEG_SCF_FBW7_1

Location: 262:269

E3 ligase: FBXW7

DEGRON score: 0.9935

ASA_SCORE: 89.4625

COIL: 0.9464

CONS_SCORE: 0.358

DSS_SCORE: 0.6711

HELIX: 0.0145

FCONS_SCORE: 1.0465

RIG_SCORE: 0.6237

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P275S	TCGA-AP-A05N	UCEC	TCGA	LLPTPRPS	DEG_SCF_FBW7_1	0.1667
p.P275S	DO229268	THCA	ICGC	LLPTPRPS	DEG_SCF_FBW7_1	0.1667
p.P275S	DO40851	UCEC	ICGC	LLPTPRPS	DEG_SCF_FBW7_1	0.1667
p.P275S	SIDM00841	Colorectal Carcinoma	GDSC	LLPTPRPS	DEG_SCF_FBW7_1	0.1667
p.P275S	ACH-000651	Colon/Colorectal Cancer	CCLE	LLPTPRPS	DEG_SCF_FBW7_1	0.1667
p.P275S	ACH-000842	Colon/Colorectal Cancer	CCLE	LLPTPRPS	DEG_SCF_FBW7_1	0.1667
p.P275S	SW620	large_intestine	COSMIC	LLPTPRPS	DEG_SCF_FBW7_1	0.1667
p.L252M	TCGA-DD-A1EB	LIHC	TCGA	LLPTPRPS	DEG_SCF_FBW7_1	0.0556
p.L252M	DO22836	LIHC	ICGC	LLPTPRPS	DEG_SCF_FBW7_1	0.0556
p.S277P	DO231207	LUSC	ICGC	LLPTPRPS	DEG_SCF_FBW7_1	0.1111
p.K256E	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LLPTPRPS	DEG_SCF_FBW7_1	0.2778
p.K256E	ACH-002256	Leukemia	CCLE	LLPTPRPS	DEG_SCF_FBW7_1	0.2778
p.K256E	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPRPS	DEG_SCF_FBW7_1	0.2778
p.R272Q	SIDM00769	Non-Small Cell Lung Carcinoma	GDSC	LLPTPRPS	DEG_SCF_FBW7_1	0.25
p.R267Q	SIDM01112	Osteosarcoma	GDSC	LLPTPRPS	DEG_SCF_FBW7_1	0.6218
p.R267Q	ACH-000748	Bone Cancer	CCLE	LLPTPRPS	DEG_SCF_FBW7_1	0.6218
p.R267Q	SJSA-1	bone	COSMIC	LLPTPRPS	DEG_SCF_FBW7_1	0.6218

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BTV7	CDK5 and ABL1 enzyme substrate 2	DEG_SCF_FBW7_1	262:269	LLPTPRPS	FBXW7	0.9935	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons