DegronMD - Q9BTV7(CABLES2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P275S	TCGA-AP-A05N	UCEC	TCGA	LLPTPRPS	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.1667
p.P275S	DO229268	THCA	ICGC	LLPTPRPS	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.1667
p.P275S	DO40851	UCEC	ICGC	LLPTPRPS	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.1667
p.P275S	SIDM00841	Colorectal Carcinoma	GDSC	LLPTPRPS	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.1667
p.P275S	ACH-000651	Colon/Colorectal Cancer	CCLE	LLPTPRPS	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.1667
p.P275S	ACH-000842	Colon/Colorectal Cancer	CCLE	LLPTPRPS	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.1667
p.P275S	SW620	large intestine	COSMIC	LLPTPRPS	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.1667
p.R128H	TCGA-B5-A3FC	UCEC	TCGA	QRCSLEFLE	DEG_APCC_DBOX_1	127:135	Mutation altering degron motif	0.8244
p.R128H	DO41871	UCEC	ICGC	QRCSLEFLE	DEG_APCC_DBOX_1	127:135	Mutation altering degron motif	0.8244
p.R123Q	TCGA-C8-A12W	BRCA	TCGA	QRCSLEFLE	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.2222
p.R123Q	DO4086	BRCA	ICGC	QRCSLEFLE	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.2222
p.R184W	TCGA-D1-A103	UCEC	TCGA	VLPYGE	LIG_APCC_ABBA_1	192:197	Mutation rewiring degron network	0.1111
p.R184W	DO42312	UCEC	ICGC	VLPYGE	LIG_APCC_ABBA_1	192:197	Mutation rewiring degron network	0.1111
p.L252M	TCGA-DD-A1EB	LIHC	TCGA	LLPTPRPS	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.0556
p.L252M	DO22836	LIHC	ICGC	LLPTPRPS	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.0556
p.G196V	TCGA-EB-A299	SKCM	TCGA	VLPYGE	LIG_APCC_ABBA_1	192:197	Mutation altering degron motif	0.6421
p.G196V	TCGA-EE-A29X	SKCM	TCGA	VLPYGE	LIG_APCC_ABBA_1	192:197	Mutation altering degron motif	0.6421
p.G196V	DO37595	SKCM	ICGC	VLPYGE	LIG_APCC_ABBA_1	192:197	Mutation altering degron motif	0.6421
p.G196V	DO37794	SKCM	ICGC	VLPYGE	LIG_APCC_ABBA_1	192:197	Mutation altering degron motif	0.6421
p.R200L	TCGA-HE-7128	KIRP	TCGA	VLPYGE	LIG_APCC_ABBA_1	192:197	Mutation rewiring degron network	0.25
p.R200L	DO20796	KIRP	ICGC	VLPYGE	LIG_APCC_ABBA_1	192:197	Mutation rewiring degron network	0.25
p.D136V	DO225343	BRCA	ICGC	QRCSLEFLE	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.3056
p.C129G	DO218223	GACA	ICGC	QRCSLEFLE	DEG_APCC_DBOX_1	127:135	Mutation altering degron motif	0.6489
p.D203E	DO229018	LICA	ICGC	VLPYGE	LIG_APCC_ABBA_1	192:197	Mutation rewiring degron network	0.1667
p.S277P	DO231207	LUSC	ICGC	LLPTPRPS	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.1111
p.Y195C	DO232067	ORCA	ICGC	VLPYGE	LIG_APCC_ABBA_1	192:197	Mutation altering degron motif	0.7087
p.V192F	DO229257	THCA	ICGC	VLPYGE	LIG_APCC_ABBA_1	192:197	Mutation altering degron motif	0.5957
p.P194S	SIDM00334	Endometrial Carcinoma	GDSC	VLPYGE	LIG_APCC_ABBA_1	192:197	Mutation altering degron motif	0.6752
p.P194S	ACH-000879	Endometrial/Uterine Cancer	CCLE	VLPYGE	LIG_APCC_ABBA_1	192:197	Mutation altering degron motif	0.6752
p.P194S	MFE-296	endometrium	COSMIC	VLPYGE	LIG_APCC_ABBA_1	192:197	Mutation altering degron motif	0.6752
p.A188T	SIDM00958	Chronic Myelogenous Leukemia	GDSC	VLPYGE	LIG_APCC_ABBA_1	192:197	Mutation rewiring degron network	0.2222
p.A188T	SIDM00549	B-Lymphoblastic Leukemia	GDSC	VLPYGE	LIG_APCC_ABBA_1	192:197	Mutation rewiring degron network	0.2222
p.A188T	SIDM01448	Head and Neck Carcinoma	GDSC	VLPYGE	LIG_APCC_ABBA_1	192:197	Mutation rewiring degron network	0.2222
p.K256E	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LLPTPRPS	DEG_SCF_FBW7_1	262:269	Mutation substituting flanking lysine	0.2778
p.K256E	ACH-002256	Leukemia	CCLE	LLPTPRPS	DEG_SCF_FBW7_1	262:269	Mutation substituting flanking lysine	0.2778
p.K256E	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	LLPTPRPS	DEG_SCF_FBW7_1	262:269	Mutation substituting flanking lysine	0.2778
p.R272Q	SIDM00769	Non-Small Cell Lung Carcinoma	GDSC	LLPTPRPS	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.25
p.R267Q	SIDM01112	Osteosarcoma	GDSC	LLPTPRPS	DEG_SCF_FBW7_1	262:269	Mutation altering degron motif	0.6218
p.R267Q	ACH-000748	Bone Cancer	CCLE	LLPTPRPS	DEG_SCF_FBW7_1	262:269	Mutation altering degron motif	0.6218
p.R267Q	SJSA-1	bone	COSMIC	LLPTPRPS	DEG_SCF_FBW7_1	262:269	Mutation altering degron motif	0.6218
p.Q120H	ACH-000924	Lung Cancer	CCLE	QRCSLEFLE	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.1389
p.I201V	ACH-000953	Leukemia	CCLE	VLPYGE	LIG_APCC_ABBA_1	192:197	Mutation rewiring degron network	0.2222
p.R200Q	ACH-001560	Lung Cancer	CCLE	VLPYGE	LIG_APCC_ABBA_1	192:197	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CABLES2

UniProt ID: Q9BTV7

Entrez ID: 81928

Protein name: CDK5 and ABL1 enzyme substrate 2 (Interactor with CDK3 2) (Ik3-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CABLES2 in