DegronMD

Uniprot ID: Q9BTV7

Source protein: CDK5 and ABL1 enzyme substrate 2

Source gene: CABLES2

Class: LIG_APCC_ABBA_1

Location: 192:197

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7818

ASA_SCORE: 49.9167

COIL: 0.6433

CONS_SCORE: 0.5111

DSS_SCORE: 0.0692

HELIX: 0.0492

FCONS_SCORE: 1.2637

RIG_SCORE: 0.8145

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R184W	TCGA-D1-A103	UCEC	TCGA	VLPYGE	LIG_APCC_ABBA_1	0.1111
p.R184W	DO42312	UCEC	ICGC	VLPYGE	LIG_APCC_ABBA_1	0.1111
p.G196V	TCGA-EB-A299	SKCM	TCGA	VLPYGE	LIG_APCC_ABBA_1	0.6421
p.G196V	TCGA-EE-A29X	SKCM	TCGA	VLPYGE	LIG_APCC_ABBA_1	0.6421
p.G196V	DO37595	SKCM	ICGC	VLPYGE	LIG_APCC_ABBA_1	0.6421
p.G196V	DO37794	SKCM	ICGC	VLPYGE	LIG_APCC_ABBA_1	0.6421
p.R200L	TCGA-HE-7128	KIRP	TCGA	VLPYGE	LIG_APCC_ABBA_1	0.25
p.R200L	DO20796	KIRP	ICGC	VLPYGE	LIG_APCC_ABBA_1	0.25
p.D203E	DO229018	LICA	ICGC	VLPYGE	LIG_APCC_ABBA_1	0.1667
p.Y195C	DO232067	ORCA	ICGC	VLPYGE	LIG_APCC_ABBA_1	0.7087
p.V192F	DO229257	THCA	ICGC	VLPYGE	LIG_APCC_ABBA_1	0.5957
p.P194S	SIDM00334	Endometrial Carcinoma	GDSC	VLPYGE	LIG_APCC_ABBA_1	0.6752
p.P194S	ACH-000879	Endometrial/Uterine Cancer	CCLE	VLPYGE	LIG_APCC_ABBA_1	0.6752
p.P194S	MFE-296	endometrium	COSMIC	VLPYGE	LIG_APCC_ABBA_1	0.6752
p.A188T	SIDM00958	Chronic Myelogenous Leukemia	GDSC	VLPYGE	LIG_APCC_ABBA_1	0.2222
p.A188T	SIDM00549	B-Lymphoblastic Leukemia	GDSC	VLPYGE	LIG_APCC_ABBA_1	0.2222
p.A188T	SIDM01448	Head and Neck Carcinoma	GDSC	VLPYGE	LIG_APCC_ABBA_1	0.2222
p.I201V	ACH-000953	Leukemia	CCLE	VLPYGE	LIG_APCC_ABBA_1	0.2222
p.R200Q	ACH-001560	Lung Cancer	CCLE	VLPYGE	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BTV7	CDK5 and ABL1 enzyme substrate 2	LIG_APCC_ABBA_1	192:197	VLPYGE	APC,CDC20,FZR1	0.7818	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons