DegronMD

Uniprot ID: Q9BTV7

Source protein: CDK5 and ABL1 enzyme substrate 2

Source gene: CABLES2

Class: DEG_APCC_DBOX_1

Location: 127:135

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7055

ASA_SCORE: 93.7111

COIL: 0.4867

CONS_SCORE: 0.3444

DSS_SCORE: 0.3313

HELIX: 0.3974

FCONS_SCORE: 1.0405

RIG_SCORE: 0.8087

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R128H	TCGA-B5-A3FC	UCEC	TCGA	QRCSLEFLE	DEG_APCC_DBOX_1	0.8244
p.R128H	DO41871	UCEC	ICGC	QRCSLEFLE	DEG_APCC_DBOX_1	0.8244
p.R123Q	TCGA-C8-A12W	BRCA	TCGA	QRCSLEFLE	DEG_APCC_DBOX_1	0.2222
p.R123Q	DO4086	BRCA	ICGC	QRCSLEFLE	DEG_APCC_DBOX_1	0.2222
p.D136V	DO225343	BRCA	ICGC	QRCSLEFLE	DEG_APCC_DBOX_1	0.3056
p.C129G	DO218223	GACA	ICGC	QRCSLEFLE	DEG_APCC_DBOX_1	0.6489
p.Q120H	ACH-000924	Lung Cancer	CCLE	QRCSLEFLE	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BTV7	CDK5 and ABL1 enzyme substrate 2	DEG_APCC_DBOX_1	127:135	QRCSLEFLE	APC,CDC20,FZR1	0.7055	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons