DegronMD

Uniprot ID: Q96AD5

Source protein: Patatin-like phospholipase domain-containing protein 2

Source gene: PNPLA2

Class: DEG_SCF_FBW7_2

Location: 487:494

E3 ligase: FBXW7

DEGRON score: 0.9982

ASA_SCORE: 74.225

COIL: 0.8328

CONS_SCORE: 0.2349

DSS_SCORE: 0.5634

HELIX: 0.0676

FCONS_SCORE: 1.0187

RIG_SCORE: 0.6454

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L481P	DO229013	COCA	ICGC	LLSTPAPE	DEG_SCF_FBW7_2	0.1667
p.L481P	DO229016	COCA	ICGC	LLSTPAPE	DEG_SCF_FBW7_2	0.1667
p.L481P	DO229003	COCA	ICGC	LLSTPAPE	DEG_SCF_FBW7_2	0.1667
p.L481P	DO229005	COCA	ICGC	LLSTPAPE	DEG_SCF_FBW7_2	0.1667
p.L481P	DO229140	THCA	ICGC	LLSTPAPE	DEG_SCF_FBW7_2	0.1667
p.L481P	DO229085	THCA	ICGC	LLSTPAPE	DEG_SCF_FBW7_2	0.1667
p.G483R	SIDM00782	Colorectal Carcinoma	GDSC	LLSTPAPE	DEG_SCF_FBW7_2	0.2222
p.P477R	SIDM00785	Acute Myeloid Leukemia	GDSC	LLSTPAPE	DEG_SCF_FBW7_2	0.0556
p.S489I	SIDM01577	Plasma Cell Myeloma	GDSC	LLSTPAPE	DEG_SCF_FBW7_2	0.623
p.H479R	ACH-000990	Endometrial/Uterine Cancer	CCLE	LLSTPAPE	DEG_SCF_FBW7_2	0.1111
p.E494K	ACH-000990	Endometrial/Uterine Cancer	CCLE	LLSTPAPE	DEG_SCF_FBW7_2	0.7022
p.A492G	ACH-000994	Endometrial/Uterine Cancer	CCLE	LLSTPAPE	DEG_SCF_FBW7_2	0.6429

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96AD5	Patatin-like phospholipase domain-containing protein 2	DEG_SCF_FBW7_2	487:494	LLSTPAPE	FBXW7	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons