DegronMD

Uniprot ID: P06865

Source protein: Beta-hexosaminidase subunit alpha

Source gene: HEXA

Class: DEG_SCF_FBW7_1

Location: 273:279

E3 ligase: FBXW7

DEGRON score: 0.7431

ASA_SCORE: 35.9

COIL: 0.7614

CONS_SCORE: 0.3663

DSS_SCORE: 0.3775

HELIX: 0.0666

FCONS_SCORE: 0.9055

RIG_SCORE: 0.7413

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W266G	TCGA-B2-4098	KIRC	TCGA	LLTPCYS	DEG_SCF_FBW7_1	0.1389
p.T286A	TCGA-CV-5973	HNSC	TCGA	LLTPCYS	DEG_SCF_FBW7_1	0.1389
p.C277Y	TCGA-MX-A663	STAD	TCGA	LLTPCYS	DEG_SCF_FBW7_1	0.5976
p.E274Q	DO2401	BRCA	ICGC	LLTPCYS	DEG_SCF_FBW7_1	0.6744
p.I263V	DO229010	COCA	ICGC	LLTPCYS	DEG_SCF_FBW7_1	0.0556
p.I263V	DO229013	COCA	ICGC	LLTPCYS	DEG_SCF_FBW7_1	0.0556
p.I263V	DO229016	COCA	ICGC	LLTPCYS	DEG_SCF_FBW7_1	0.0556
p.I263V	DO229003	COCA	ICGC	LLTPCYS	DEG_SCF_FBW7_1	0.0556
p.I263V	DO229005	COCA	ICGC	LLTPCYS	DEG_SCF_FBW7_1	0.0556
p.G271S	DO23561	LUAD	ICGC	LLTPCYS	DEG_SCF_FBW7_1	0.2778
p.P273T	DO39552	THCA	ICGC	LLTPCYS	DEG_SCF_FBW7_1	0.7031
p.S279C	CHSA8926	bone	COSMIC	LLTPCYS	DEG_SCF_FBW7_1	0.7541

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P06865	Beta-hexosaminidase subunit alpha	DEG_SCF_FBW7_1	273:279	LLTPCYS	FBXW7	0.7431	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons