DegronMD

Uniprot ID: P49796

Source protein: Regulator of G-protein signaling 3

Source gene: RGS3

Class: DEG_SCF_FBW7_2

Location: 245:251

E3 ligase: FBXW7

DEGRON score: 0.8173

ASA_SCORE: 74.8429

COIL: 0.7646

CONS_SCORE: 0.3258

DSS_SCORE: 0.0631

HELIX: 0.128

FCONS_SCORE: 1.1722

RIG_SCORE: 0.8101

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E261D	TCGA-38-4631	LUAD	TCGA	LLTPDKE	DEG_SCF_FBW7_2	0.0556
p.T247I	TCGA-AX-A2HD	UCEC	TCGA	LLTPDKE	DEG_SCF_FBW7_2	0.7078
p.G241R	TCGA-EE-A20C	SKCM	TCGA	LLTPDKE	DEG_SCF_FBW7_2	0.2222
p.G241R	DO222775	MELA	ICGC	LLTPDKE	DEG_SCF_FBW7_2	0.2222
p.G241R	DO47665	SKCM	ICGC	LLTPDKE	DEG_SCF_FBW7_2	0.2222
p.R236C	DO9314	COAD	ICGC	LLTPDKE	DEG_SCF_FBW7_2	0.0833
p.G240D	DO230346	COCA	ICGC	LLTPDKE	DEG_SCF_FBW7_2	0.1944
p.A254T	DO44440	HNSC	ICGC	LLTPDKE	DEG_SCF_FBW7_2	0.25
p.H241Q	DO223947	KIRP	ICGC	LLTPDKE	DEG_SCF_FBW7_2	0.2222
p.R237S	DO229035	LICA	ICGC	LLTPDKE	DEG_SCF_FBW7_2	0.1111
p.V237L	DO229037	LICA	ICGC	LLTPDKE	DEG_SCF_FBW7_2	0.1111
p.C242Y	DO52185	LIHC	ICGC	LLTPDKE	DEG_SCF_FBW7_2	0.25
p.P252L	DO24596	LUAD	ICGC	LLTPDKE	DEG_SCF_FBW7_2	0.3056
p.R260C	DO38186	STAD	ICGC	LLTPDKE	DEG_SCF_FBW7_2	0.0833
p.R253H	DO229211	THCA	ICGC	LLTPDKE	DEG_SCF_FBW7_2	0.2778
p.S244F	ACH-002396	Bone Cancer	CCLE	LLTPDKE	DEG_SCF_FBW7_2	0.3056
p.S244F	Sarc9371	bone	COSMIC	LLTPDKE	DEG_SCF_FBW7_2	0.3056
p.K237T	HT-115	large_intestine	COSMIC	LLTPDKE	DEG_SCF_FBW7_2	0.1111
p.V245M	LNCaP-Clone-FGC	prostate	COSMIC	LLTPDKE	DEG_SCF_FBW7_2	0.7208
p.E253D	SW948	large_intestine	COSMIC	LLTPDKE	DEG_SCF_FBW7_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49796	Regulator of G-protein signaling 3	DEG_SCF_FBW7_2	245:251	LLTPDKE	FBXW7	0.8173	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons