DegronMD

Uniprot ID: Q96H15

Source protein: T-cell immunoglobulin and mucin domain-containing protein 4

Source gene: TIMD4

Class: DEG_SCF_FBW7_1

Location: 212:218

E3 ligase: FBXW7

DEGRON score: 0.985

ASA_SCORE: 75.8857

COIL: 0.7629

CONS_SCORE: 0.2687

DSS_SCORE: 0.6502

HELIX: 0.023

FCONS_SCORE: 0.6936

RIG_SCORE: 0.6938

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G211V	TCGA-17-Z026	LUAD	TCGA	LLTPEPS	DEG_SCF_FBW7_1	0.3056
p.T210I	TCGA-21-5787	LUSC	TCGA	LLTPEPS	DEG_SCF_FBW7_1	0.2778
p.T210I	DO26605	LUSC	ICGC	LLTPEPS	DEG_SCF_FBW7_1	0.2778
p.P206Q	TCGA-55-7994	LUAD	TCGA	LLTPEPS	DEG_SCF_FBW7_1	0.1667
p.P206Q	DO45311	LUAD	ICGC	LLTPEPS	DEG_SCF_FBW7_1	0.1667
p.S203N	TCGA-56-1622	LUSC	TCGA	LLTPEPS	DEG_SCF_FBW7_1	0.0833
p.S203N	DO26461	LUSC	ICGC	LLTPEPS	DEG_SCF_FBW7_1	0.0833
p.P217H	TCGA-77-A5G6	LUSC	TCGA	LLTPEPS	DEG_SCF_FBW7_1	0.6583
p.P217H	DO50097	LUSC	ICGC	LLTPEPS	DEG_SCF_FBW7_1	0.6583
p.L205I	TCGA-CC-A8HT	LIHC	TCGA	LLTPEPS	DEG_SCF_FBW7_1	0.1389
p.L205I	DO52187	LIHC	ICGC	LLTPEPS	DEG_SCF_FBW7_1	0.1389
p.E208K	TCGA-D3-A2JP	SKCM	TCGA	LLTPEPS	DEG_SCF_FBW7_1	0.2222
p.E208K	DO229456	SKCA	ICGC	LLTPEPS	DEG_SCF_FBW7_1	0.2222
p.E208K	DO47407	SKCM	ICGC	LLTPEPS	DEG_SCF_FBW7_1	0.2222
p.P202T	TCGA-NC-A5HI	LUSC	TCGA	LLTPEPS	DEG_SCF_FBW7_1	0.0556
p.P202T	DO45461	LUSC	ICGC	LLTPEPS	DEG_SCF_FBW7_1	0.0556
p.P202S	TCGA-R8-A6MO	LGG	TCGA	LLTPEPS	DEG_SCF_FBW7_1	0.0556
p.P202S	DO48508	LGG	ICGC	LLTPEPS	DEG_SCF_FBW7_1	0.0556
p.S228L	TCGA-T2-A6X0	HNSC	TCGA	LLTPEPS	DEG_SCF_FBW7_1	0.0556
p.S228L	DO219069	HNSC	ICGC	LLTPEPS	DEG_SCF_FBW7_1	0.0556
p.G221E	TCGA-Z2-A8RT	SKCM	TCGA	LLTPEPS	DEG_SCF_FBW7_1	0.25
p.G221E	DO51301	SKCM	ICGC	LLTPEPS	DEG_SCF_FBW7_1	0.25
p.E216A	DO217814	GACA	ICGC	LLTPEPS	DEG_SCF_FBW7_1	0.659
p.P215S	DO220862	MELA	ICGC	LLTPEPS	DEG_SCF_FBW7_1	0.6752
p.E220K	DO220877	MELA	ICGC	LLTPEPS	DEG_SCF_FBW7_1	0.2778
p.E207K	DO229446	SKCA	ICGC	LLTPEPS	DEG_SCF_FBW7_1	0.1944
p.T204I	SIDM01104	Melanoma	GDSC	LLTPEPS	DEG_SCF_FBW7_1	0.1111
p.T204I	ACH-000640	Skin Cancer	CCLE	LLTPEPS	DEG_SCF_FBW7_1	0.1111
p.T204I	SK-MEL-31	skin	COSMIC	LLTPEPS	DEG_SCF_FBW7_1	0.1111
p.E216K	SIDM00291	Melanoma	GDSC	LLTPEPS	DEG_SCF_FBW7_1	0.591
p.E216K	SIDM01433	Kidney Carcinoma	GDSC	LLTPEPS	DEG_SCF_FBW7_1	0.591
p.E216K	HMV-II	skin	COSMIC	LLTPEPS	DEG_SCF_FBW7_1	0.591

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LLTPEPS

Degron related mutations and impact score

Drug responses associated with TIMD4 mutations

All proteins holding degron of LLTPEPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96H15	T-cell immunoglobulin and mucin domain-containing protein 4	DEG_SCF_FBW7_1	212:218	LLTPEPS	FBXW7	0.985	More...