DegronMD

Uniprot ID: O94967

Source protein: WD repeat-containing protein 47

Source gene: WDR47

Class: DEG_SCF_FBW7_1

Location: 283:289

E3 ligase: FBXW7

DEGRON score: 0.9859

ASA_SCORE: 67.0857

COIL: 0.7493

CONS_SCORE: 0.4704

DSS_SCORE: 0.2293

HELIX: 0.1437

FCONS_SCORE: 1.2321

RIG_SCORE: 0.8154

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A288V	TCGA-06-5416	GBM	TCGA	LLTPLIS	DEG_SCF_FBW7_1	0.6936
p.T292I	TCGA-14-0867	GBM	TCGA	LLTPLIS	DEG_SCF_FBW7_1	0.6944
p.L291V	TCGA-BH-A1FG	BRCA	TCGA	LLTPLIS	DEG_SCF_FBW7_1	0.2778
p.L294R	TCGA-CA-6717	COAD	TCGA	LLTPLIS	DEG_SCF_FBW7_1	0.1944
p.H275N	TCGA-MV-A51V	BLCA	TCGA	LLTPLIS	DEG_SCF_FBW7_1	0.1111
p.V276F	TCGA-NC-A5HR	LUSC	TCGA	LLTPLIS	DEG_SCF_FBW7_1	0.1389
p.Q275R	DO52318	LIHC	ICGC	LLTPLIS	DEG_SCF_FBW7_1	0.1111
p.S284F	DO37487	SKCM	ICGC	LLTPLIS	DEG_SCF_FBW7_1	0.7982
p.R283H	DO47981	STAD	ICGC	LLTPLIS	DEG_SCF_FBW7_1	0.8244
p.R283H	DO52409	UCEC	ICGC	LLTPLIS	DEG_SCF_FBW7_1	0.8244
p.R283H	DO43891	UCEC	ICGC	LLTPLIS	DEG_SCF_FBW7_1	0.8244
p.L289F	IGROV-1	ovary	COSMIC	LLTPLIS	DEG_SCF_FBW7_1	0.6981
p.L289F	NCI-H510A	lung	COSMIC	LLTPLIS	DEG_SCF_FBW7_1	0.6981

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94967	WD repeat-containing protein 47	DEG_SCF_FBW7_1	283:289	LLTPLIS	FBXW7	0.9859	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons