DegronMD

Uniprot ID: Q14244

Source protein: Ensconsin

Source gene: MAP7

Class: DEG_SCF_FBW7_1

Location: 229:235

E3 ligase: FBXW7

DEGRON score: 0.9637

ASA_SCORE: 95.4857

COIL: 0.7943

CONS_SCORE: 0.7329

DSS_SCORE: 0.2799

HELIX: 0.171

FCONS_SCORE: 1.0635

RIG_SCORE: 0.772

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R234K	TCGA-EE-A29G	SKCM	TCGA	LLTPTHS	DEG_SCF_FBW7_1	0.7237
p.S231Y	TCGA-F5-6814	READ	TCGA	LLTPTHS	DEG_SCF_FBW7_1	0.712
p.S231Y	DO36556	READ	ICGC	LLTPTHS	DEG_SCF_FBW7_1	0.712
p.S231Y	SIDM01611	Endometrial Carcinoma	GDSC	LLTPTHS	DEG_SCF_FBW7_1	0.712
p.R220P	TCGA-L9-A8F4	LUAD	TCGA	LLTPTHS	DEG_SCF_FBW7_1	0.0833
p.R220P	DO49876	LUAD	ICGC	LLTPTHS	DEG_SCF_FBW7_1	0.0833
p.T231M	DO222427	BTCA	ICGC	LLTPTHS	DEG_SCF_FBW7_1	0.8534
p.R239T	DO219026	HNSC	ICGC	LLTPTHS	DEG_SCF_FBW7_1	0.2222
p.P220T	DO228986	LICA	ICGC	LLTPTHS	DEG_SCF_FBW7_1	0.0833
p.L221F	DO218863	SKCA	ICGC	LLTPTHS	DEG_SCF_FBW7_1	0.1111
p.L230M	ACH-000351	Gastric Cancer	CCLE	LLTPTHS	DEG_SCF_FBW7_1	0.5999
p.L230M	MKN1	stomach	COSMIC	LLTPTHS	DEG_SCF_FBW7_1	0.5999
p.H234Y	ACH-001452	Leukemia	CCLE	LLTPTHS	DEG_SCF_FBW7_1	0.6118
p.H234Y	BONNA-12	haematopoietic_and_lymphoid_tissue	COSMIC	LLTPTHS	DEG_SCF_FBW7_1	0.6118
p.S231L	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	LLTPTHS	DEG_SCF_FBW7_1	0.7667
p.S231L	HCC2998	large_intestine	COSMIC	LLTPTHS	DEG_SCF_FBW7_1	0.7667
p.R234L	JHH-7	liver	COSMIC	LLTPTHS	DEG_SCF_FBW7_1	0.8428
p.H219Y	BONNA-12	haematopoietic_and_lymphoid_tissue	COSMIC	LLTPTHS	DEG_SCF_FBW7_1	0.5
p.P235Q	COR-L321	NS	COSMIC	LLTPTHS	DEG_SCF_FBW7_1	0.7035
p.A219V	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	LLTPTHS	DEG_SCF_FBW7_1	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14244	Ensconsin	DEG_SCF_FBW7_1	229:235	LLTPTHS	FBXW7	0.9637	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons