DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
LLVFCE
Uniprot ID:
P16885
Source protein:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
Source gene:
PLCG2
Class:
LIG_APCC_ABBA_1
Location:
1180:1185
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6083
ASA_SCORE:
20.3667
COIL:
0.014
CONS_SCORE:
0.5496
DSS_SCORE:
0.0807
HELIX:
0.0022
FCONS_SCORE:
1.3725
RIG_SCORE:
0.9161
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R1187W
TCGA-28-1757
GBM
TCGA
LLVFCE
LIG_APCC_ABBA_1
0.2778
p.R1187W
DO12166
GBM
ICGC
LLVFCE
LIG_APCC_ABBA_1
0.2778
p.R1187W
DO23108
LINC
ICGC
LLVFCE
LIG_APCC_ABBA_1
0.2778
p.E1194D
TCGA-AA-3510
COAD
TCGA
LLVFCE
LIG_APCC_ABBA_1
0.0833
p.E1194D
DO7783
COAD
ICGC
LLVFCE
LIG_APCC_ABBA_1
0.0833
p.V1182L
TCGA-CR-7402
HNSC
TCGA
LLVFCE
LIG_APCC_ABBA_1
0.5654
p.V1182L
DO15727
HNSC
ICGC
LLVFCE
LIG_APCC_ABBA_1
0.5654
p.S1172T
DO222884
COCA
ICGC
LLVFCE
LIG_APCC_ABBA_1
0.1111
p.E1176D
DO234222
ESAD
ICGC
LLVFCE
LIG_APCC_ABBA_1
0.2222
p.A1178T
DO220891
MELA
ICGC
LLVFCE
LIG_APCC_ABBA_1
0.2778
p.R1187Q
DO222395
MELA
ICGC
LLVFCE
LIG_APCC_ABBA_1
0.2778
p.R1187Q
SIDM00929
Chondrosarcoma
GDSC
LLVFCE
LIG_APCC_ABBA_1
0.2778
p.R1187Q
ACH-000516
Bone Cancer
CCLE
LLVFCE
LIG_APCC_ABBA_1
0.2778
p.R1187Q
CAL-78
bone
COSMIC
LLVFCE
LIG_APCC_ABBA_1
0.2778
Drug responses associated with PLCG2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LLVFCE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P16885
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
LIG_APCC_ABBA_1
1180:1185
LLVFCE
APC,CDC20,FZR1
0.6083
More...