DegronMD

Uniprot ID: P16885

Source protein: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

Source gene: PLCG2

Class: LIG_APCC_ABBA_1

Location: 1180:1185

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6083

ASA_SCORE: 20.3667

COIL: 0.014

CONS_SCORE: 0.5496

DSS_SCORE: 0.0807

HELIX: 0.0022

FCONS_SCORE: 1.3725

RIG_SCORE: 0.9161

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1182L	TCGA-CR-7402	HNSC	TCGA	LLVFCE	LIG_APCC_ABBA_1	0.5654
p.V1182L	DO15727	HNSC	ICGC	LLVFCE	LIG_APCC_ABBA_1	0.5654
p.R1187W	TCGA-28-1757	GBM	TCGA	LLVFCE	LIG_APCC_ABBA_1	0.2778
p.R1187W	DO12166	GBM	ICGC	LLVFCE	LIG_APCC_ABBA_1	0.2778
p.R1187W	DO23108	LINC	ICGC	LLVFCE	LIG_APCC_ABBA_1	0.2778
p.A1178T	DO220891	MELA	ICGC	LLVFCE	LIG_APCC_ABBA_1	0.2778
p.R1187Q	DO222395	MELA	ICGC	LLVFCE	LIG_APCC_ABBA_1	0.2778
p.R1187Q	SIDM00929	Chondrosarcoma	GDSC	LLVFCE	LIG_APCC_ABBA_1	0.2778
p.R1187Q	ACH-000516	Bone Cancer	CCLE	LLVFCE	LIG_APCC_ABBA_1	0.2778
p.R1187Q	CAL-78	bone	COSMIC	LLVFCE	LIG_APCC_ABBA_1	0.2778
p.E1176D	DO234222	ESAD	ICGC	LLVFCE	LIG_APCC_ABBA_1	0.2222
p.S1172T	DO222884	COCA	ICGC	LLVFCE	LIG_APCC_ABBA_1	0.1111
p.E1194D	TCGA-AA-3510	COAD	TCGA	LLVFCE	LIG_APCC_ABBA_1	0.0833
p.E1194D	DO7783	COAD	ICGC	LLVFCE	LIG_APCC_ABBA_1	0.0833

Showing 1 to 14 of 14 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	LIG_APCC_ABBA_1	1180:1185	LLVFCE	APC,CDC20,FZR1	0.6083	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons