DegronMD - P16885(PLCG2)

GO - Biological processes (BP): activation of store-operated calcium channel activity [GO:0032237]; antifungal innate immune response [GO:0061760]; B cell differentiation [GO:0030183]; B cell receptor signaling pathway [GO:0050853]; calcium-mediated signaling [GO:0019722]; cell activation [GO:0001775]; cellular response to calcium ion [GO:0071277]; cellular response to lectin [GO:1990858]; cellular response to lipid [GO:0071396]; Fc-epsilon receptor signaling pathway [GO:0038095]; follicular B cell differentiation [GO:0002316]; inositol trisphosphate biosynthetic process [GO:0032959]; intracellular signal transduction [GO:0035556]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; macrophage activation involved in immune response [GO:0002281]; negative regulation of programmed cell death [GO:0043069]; phosphatidylinositol biosynthetic process [GO:0006661]; phospholipid catabolic process [GO:0009395]; platelet activation [GO:0030168]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of dendritic cell cytokine production [GO:0002732]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of gene expression [GO:0010628]; positive regulation of I-kappaB phosphorylation [GO:1903721]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-23 production [GO:0032747]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuroinflammatory response [GO:0150078]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of receptor internalization [GO:0002092]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I interferon production [GO:0032481]; regulation of calcineurin-NFAT signaling cascade [GO:0070884]; regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122]; regulation of lipid metabolic process [GO:0019216]; release of sequestered calcium ion into cytosol [GO:0051209]; response to axon injury [GO:0048678]; response to yeast [GO:0001878]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell receptor signaling pathway [GO:0050852]; toll-like receptor signaling pathway [GO:0002224]; Wnt signaling pathway [GO:0016055] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1187W	TCGA-28-1757	GBM	TCGA	LLVFCE	LIG_APCC_ABBA_1	1180:1185	Mutation rewiring degron network	0.2778
p.R1187W	DO12166	GBM	ICGC	LLVFCE	LIG_APCC_ABBA_1	1180:1185	Mutation rewiring degron network	0.2778
p.R1187W	DO23108	LINC	ICGC	LLVFCE	LIG_APCC_ABBA_1	1180:1185	Mutation rewiring degron network	0.2778
p.G1069S	TCGA-A5-A0G9	UCEC	TCGA	QRKILMTLT	DEG_APCC_DBOX_1	1056:1064	Mutation rewiring degron network	0.1944
p.G1069S	DO42304	UCEC	ICGC	QRKILMTLT	DEG_APCC_DBOX_1	1056:1064	Mutation rewiring degron network	0.1944
p.E1194D	TCGA-AA-3510	COAD	TCGA	LLVFCE	LIG_APCC_ABBA_1	1180:1185	Mutation rewiring degron network	0.0833
p.E1194D	DO7783	COAD	ICGC	LLVFCE	LIG_APCC_ABBA_1	1180:1185	Mutation rewiring degron network	0.0833
p.E1046D	TCGA-BS-A0UF	UCEC	TCGA	QRKILMTLT	DEG_APCC_DBOX_1	1056:1064	Mutation rewiring degron network	0.0556
p.E1046D	DO41488	UCEC	ICGC	QRKILMTLT	DEG_APCC_DBOX_1	1056:1064	Mutation rewiring degron network	0.0556
p.V1182L	TCGA-CR-7402	HNSC	TCGA	LLVFCE	LIG_APCC_ABBA_1	1180:1185	Mutation altering degron motif	0.5654
p.V1182L	DO15727	HNSC	ICGC	LLVFCE	LIG_APCC_ABBA_1	1180:1185	Mutation altering degron motif	0.5654
p.T1062S	TCGA-D1-A103	UCEC	TCGA	QRKILMTLT	DEG_APCC_DBOX_1	1056:1064	Mutation altering degron motif	0.7116
p.T1062S	DO42312	UCEC	ICGC	QRKILMTLT	DEG_APCC_DBOX_1	1056:1064	Mutation altering degron motif	0.7116
p.G1069C	TCGA-D3-A2JP	SKCM	TCGA	QRKILMTLT	DEG_APCC_DBOX_1	1056:1064	Mutation rewiring degron network	0.1944
p.G1069C	TCGA-D3-A3C7	SKCM	TCGA	QRKILMTLT	DEG_APCC_DBOX_1	1056:1064	Mutation rewiring degron network	0.1944
p.G1069C	DO47407	SKCM	ICGC	QRKILMTLT	DEG_APCC_DBOX_1	1056:1064	Mutation rewiring degron network	0.1944
p.G1069C	DO47569	SKCM	ICGC	QRKILMTLT	DEG_APCC_DBOX_1	1056:1064	Mutation rewiring degron network	0.1944
p.P1074S	TCGA-W3-AA1R	SKCM	TCGA	QRKILMTLT	DEG_APCC_DBOX_1	1056:1064	Mutation rewiring degron network	0.0556
p.P1074S	DO51275	SKCM	ICGC	QRKILMTLT	DEG_APCC_DBOX_1	1056:1064	Mutation rewiring degron network	0.0556
p.S1172T	DO222884	COCA	ICGC	LLVFCE	LIG_APCC_ABBA_1	1180:1185	Mutation rewiring degron network	0.1111
p.E1176D	DO234222	ESAD	ICGC	LLVFCE	LIG_APCC_ABBA_1	1180:1185	Mutation rewiring degron network	0.2222
p.A1178T	DO220891	MELA	ICGC	LLVFCE	LIG_APCC_ABBA_1	1180:1185	Mutation rewiring degron network	0.2778
p.R1187Q	DO222395	MELA	ICGC	LLVFCE	LIG_APCC_ABBA_1	1180:1185	Mutation rewiring degron network	0.2778
p.R1187Q	SIDM00929	Chondrosarcoma	GDSC	LLVFCE	LIG_APCC_ABBA_1	1180:1185	Mutation rewiring degron network	0.2778
p.R1187Q	ACH-000516	Bone Cancer	CCLE	LLVFCE	LIG_APCC_ABBA_1	1180:1185	Mutation rewiring degron network	0.2778
p.R1187Q	CAL-78	bone	COSMIC	LLVFCE	LIG_APCC_ABBA_1	1180:1185	Mutation rewiring degron network	0.2778
p.P1052L	DO222843	MELA	ICGC	QRKILMTLT	DEG_APCC_DBOX_1	1056:1064	Mutation rewiring degron network	0.2222
p.H1072Q	SIDM00525	Osteosarcoma	GDSC	QRKILMTLT	DEG_APCC_DBOX_1	1056:1064	Mutation rewiring degron network	0.1111
p.H1072Q	ACH-000359	Bone Cancer	CCLE	QRKILMTLT	DEG_APCC_DBOX_1	1056:1064	Mutation rewiring degron network	0.1111
p.H1072Q	MG-63	bone	COSMIC	QRKILMTLT	DEG_APCC_DBOX_1	1056:1064	Mutation rewiring degron network	0.1111
p.K1066N	SIDM00282	Colorectal Carcinoma	GDSC	QRKILMTLT	DEG_APCC_DBOX_1	1056:1064	Mutation rewiring degron network	0.2778
p.K1066N	CW-2	large intestine	COSMIC	QRKILMTLT	DEG_APCC_DBOX_1	1056:1064	Mutation rewiring degron network	0.2778
p.P1050Q	SIDM01086	B-Lymphoblastic Leukemia	GDSC	QRKILMTLT	DEG_APCC_DBOX_1	1056:1064	Mutation rewiring degron network	0.1667
p.P1050Q	ACH-000874	Leukemia	CCLE	QRKILMTLT	DEG_APCC_DBOX_1	1056:1064	Mutation rewiring degron network	0.1667
p.P1050Q	RS4-11	haematopoietic and lymphoid tissue	COSMIC	QRKILMTLT	DEG_APCC_DBOX_1	1056:1064	Mutation rewiring degron network	0.1667
p.R1071H	ACH-001991	Primary	CCLE	QRKILMTLT	DEG_APCC_DBOX_1	1056:1064	Mutation rewiring degron network	0.1389

Kaplan plot for PLCG2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLCG2

UniProt ID: P16885

Entrez ID: 5336

Protein name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-IV) (PLC-IV) (Phospholipase C-gamma-2) (PLC-gamma-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PLCG2 in