DegronMD

Uniprot ID: P16885

Source protein: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

Source gene: PLCG2

Class: DEG_APCC_DBOX_1

Location: 1056:1064

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.911

ASA_SCORE: 54.4333

COIL: 0.3187

CONS_SCORE: 0.3504

DSS_SCORE: 0.3285

HELIX: 0.0962

FCONS_SCORE: 0.8105

RIG_SCORE: 0.8427

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1069S	TCGA-A5-A0G9	UCEC	TCGA	QRKILMTLT	DEG_APCC_DBOX_1	0.1944
p.G1069S	DO42304	UCEC	ICGC	QRKILMTLT	DEG_APCC_DBOX_1	0.1944
p.E1046D	TCGA-BS-A0UF	UCEC	TCGA	QRKILMTLT	DEG_APCC_DBOX_1	0.0556
p.E1046D	DO41488	UCEC	ICGC	QRKILMTLT	DEG_APCC_DBOX_1	0.0556
p.T1062S	TCGA-D1-A103	UCEC	TCGA	QRKILMTLT	DEG_APCC_DBOX_1	0.7116
p.T1062S	DO42312	UCEC	ICGC	QRKILMTLT	DEG_APCC_DBOX_1	0.7116
p.G1069C	TCGA-D3-A2JP	SKCM	TCGA	QRKILMTLT	DEG_APCC_DBOX_1	0.1944
p.G1069C	TCGA-D3-A3C7	SKCM	TCGA	QRKILMTLT	DEG_APCC_DBOX_1	0.1944
p.G1069C	DO47407	SKCM	ICGC	QRKILMTLT	DEG_APCC_DBOX_1	0.1944
p.G1069C	DO47569	SKCM	ICGC	QRKILMTLT	DEG_APCC_DBOX_1	0.1944
p.P1074S	TCGA-W3-AA1R	SKCM	TCGA	QRKILMTLT	DEG_APCC_DBOX_1	0.0556
p.P1074S	DO51275	SKCM	ICGC	QRKILMTLT	DEG_APCC_DBOX_1	0.0556
p.P1052L	DO222843	MELA	ICGC	QRKILMTLT	DEG_APCC_DBOX_1	0.2222
p.H1072Q	SIDM00525	Osteosarcoma	GDSC	QRKILMTLT	DEG_APCC_DBOX_1	0.1111
p.H1072Q	ACH-000359	Bone Cancer	CCLE	QRKILMTLT	DEG_APCC_DBOX_1	0.1111
p.H1072Q	MG-63	bone	COSMIC	QRKILMTLT	DEG_APCC_DBOX_1	0.1111
p.K1066N	SIDM00282	Colorectal Carcinoma	GDSC	QRKILMTLT	DEG_APCC_DBOX_1	0.2778
p.K1066N	CW-2	large_intestine	COSMIC	QRKILMTLT	DEG_APCC_DBOX_1	0.2778
p.P1050Q	SIDM01086	B-Lymphoblastic Leukemia	GDSC	QRKILMTLT	DEG_APCC_DBOX_1	0.1667
p.P1050Q	ACH-000874	Leukemia	CCLE	QRKILMTLT	DEG_APCC_DBOX_1	0.1667
p.P1050Q	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	QRKILMTLT	DEG_APCC_DBOX_1	0.1667
p.R1071H	ACH-001991	Primary	CCLE	QRKILMTLT	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	DEG_APCC_DBOX_1	1056:1064	QRKILMTLT	APC,CDC20,FZR1	0.911	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons