DegronMD

Uniprot ID: Q96K30

Source protein: RBPJ-interacting and tubulin-associated protein 1

Source gene: RITA1

Class: DEG_SCF_FBW7_1

Location: 140:147

E3 ligase: FBXW7

DEGRON score: 0.9985

ASA_SCORE: 58.9625

COIL: 0.7638

CONS_SCORE: 0.5896

DSS_SCORE: 0.6338

HELIX: 0.0324

FCONS_SCORE: 1.3675

RIG_SCORE: 0.6623

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R155C	TCGA-CD-8536	STAD	TCGA	LLWTPPPT	DEG_SCF_FBW7_1	0.1111
p.G150V	TCGA-LG-A6GG	LIHC	TCGA	LLWTPPPT	DEG_SCF_FBW7_1	0.25
p.A146T	SIDM00216	Colorectal Carcinoma	GDSC	LLWTPPPT	DEG_SCF_FBW7_1	0.7139
p.A146T	SNU-175	large_intestine	COSMIC	LLWTPPPT	DEG_SCF_FBW7_1	0.7139
p.R152W	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LLWTPPPT	DEG_SCF_FBW7_1	0.1944
p.R152W	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	LLWTPPPT	DEG_SCF_FBW7_1	0.1944
p.R152Q	SIDM00217	Colorectal Carcinoma	GDSC	LLWTPPPT	DEG_SCF_FBW7_1	0.1944
p.R152Q	SNU-1040	large_intestine	COSMIC	LLWTPPPT	DEG_SCF_FBW7_1	0.1944
p.P131L	SIDM01615	Non-Small Cell Lung Carcinoma	GDSC	LLWTPPPT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96K30	RBPJ-interacting and tubulin-associated protein 1	DEG_SCF_FBW7_1	140:147	LLWTPPPT	FBXW7	0.9985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons