DegronMD

Uniprot ID: Q9UPQ3

Source protein: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

Source gene: AGAP1

Class: DEG_SCF_FBW7_1

Location: 833:840

E3 ligase: FBXW7

DEGRON score: 0.998

ASA_SCORE: 61.5375

COIL: 0.7324

CONS_SCORE: 0.3174

DSS_SCORE: 0.3976

HELIX: 0.1986

FCONS_SCORE: 1.0029

RIG_SCORE: 0.8012

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P837S	TCGA-AX-A2HD	UCEC	TCGA	LMATPNLS	DEG_SCF_FBW7_1	0.6752
p.P837S	DO42608	UCEC	ICGC	LMATPNLS	DEG_SCF_FBW7_1	0.6752
p.R846Q	TCGA-BR-8487	STAD	TCGA	LMATPNLS	DEG_SCF_FBW7_1	0.1667
p.R846Q	TCGA-EE-A2GO	SKCM	TCGA	LMATPNLS	DEG_SCF_FBW7_1	0.1667
p.R846Q	DO50970	LICA	ICGC	LMATPNLS	DEG_SCF_FBW7_1	0.1667
p.R846Q	DO37823	SKCM	ICGC	LMATPNLS	DEG_SCF_FBW7_1	0.1667
p.R846Q	DO47867	STAD	ICGC	LMATPNLS	DEG_SCF_FBW7_1	0.1667
p.L833F	TCGA-CA-6717	COAD	TCGA	LMATPNLS	DEG_SCF_FBW7_1	0.6981
p.L833F	DO8264	COAD	ICGC	LMATPNLS	DEG_SCF_FBW7_1	0.6981
p.E829K	TCGA-D3-A5GU	SKCM	TCGA	LMATPNLS	DEG_SCF_FBW7_1	0.2222
p.E829K	DO47584	SKCM	ICGC	LMATPNLS	DEG_SCF_FBW7_1	0.2222
p.V832M	TCGA-D5-6928	COAD	TCGA	LMATPNLS	DEG_SCF_FBW7_1	0.3056
p.V832M	DO7776	COAD	ICGC	LMATPNLS	DEG_SCF_FBW7_1	0.3056
p.V832M	DO234199	ESAD	ICGC	LMATPNLS	DEG_SCF_FBW7_1	0.3056
p.V832M	SIDM01653	Non-Cancerous	GDSC	LMATPNLS	DEG_SCF_FBW7_1	0.3056
p.V832M	SIDM00207	Glioblastoma	GDSC	LMATPNLS	DEG_SCF_FBW7_1	0.3056
p.V832M	SIDM00217	Colorectal Carcinoma	GDSC	LMATPNLS	DEG_SCF_FBW7_1	0.3056
p.V832M	SIDM01394	Kidney Carcinoma	GDSC	LMATPNLS	DEG_SCF_FBW7_1	0.3056
p.N845D	TCGA-DD-A4NN	LIHC	TCGA	LMATPNLS	DEG_SCF_FBW7_1	0.1944
p.N845D	DO44970	LIHC	ICGC	LMATPNLS	DEG_SCF_FBW7_1	0.1944
p.P837H	TCGA-FS-A1ZM	SKCM	TCGA	LMATPNLS	DEG_SCF_FBW7_1	0.7694
p.P837H	DO37731	SKCM	ICGC	LMATPNLS	DEG_SCF_FBW7_1	0.7694
p.N848S	TCGA-RC-A6M6	LIHC	TCGA	LMATPNLS	DEG_SCF_FBW7_1	0.1111
p.N848S	DO223917	LIHC	ICGC	LMATPNLS	DEG_SCF_FBW7_1	0.1111
p.G825V	DO228978	LICA	ICGC	LMATPNLS	DEG_SCF_FBW7_1	0.1111
p.R830H	SIDM01300	Colorectal Carcinoma	GDSC	LMATPNLS	DEG_SCF_FBW7_1	0.25
p.Y824C	SIDM01045	Endometrial Carcinoma	GDSC	LMATPNLS	DEG_SCF_FBW7_1	0.0833
p.Y824C	EN	endometrium	COSMIC	LMATPNLS	DEG_SCF_FBW7_1	0.0833
p.N838S	SIDM01743	Melanoma	GDSC	LMATPNLS	DEG_SCF_FBW7_1	0.5958
p.S834C	PCI-15A	upper_aerodigestive_tract	COSMIC	LMATPNLS	DEG_SCF_FBW7_1	0.7541

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LMATPNLS

Degron related mutations and impact score

Drug responses associated with AGAP1 mutations

All proteins holding degron of LMATPNLS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPQ3	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1	DEG_SCF_FBW7_1	833:840	LMATPNLS	FBXW7	0.998	More...