DegronMD - Q9UPQ3(AGAP1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D277N	TCGA-A5-A0G2	UCEC	TCGA	VPSTPSTS	DEG_SCF_FBW7_1	282:289	Mutation rewiring degron network	0.1944
p.D277N	DO41235	UCEC	ICGC	VPSTPSTS	DEG_SCF_FBW7_1	282:289	Mutation rewiring degron network	0.1944
p.D296N	TCGA-AG-A002	READ	TCGA	VPSTPSTS	DEG_SCF_FBW7_1	282:289	Mutation rewiring degron network	0.1389
p.D296N	TCGA-CA-6717	COAD	TCGA	VPSTPSTS	DEG_SCF_FBW7_1	282:289	Mutation rewiring degron network	0.1389
p.D296N	DO8264	COAD	ICGC	VPSTPSTS	DEG_SCF_FBW7_1	282:289	Mutation rewiring degron network	0.1389
p.P837S	TCGA-AX-A2HD	UCEC	TCGA	LMATPNLS	DEG_SCF_FBW7_1	833:840	Mutation altering degron motif	0.6752
p.P837S	DO42608	UCEC	ICGC	LMATPNLS	DEG_SCF_FBW7_1	833:840	Mutation altering degron motif	0.6752
p.R846Q	TCGA-BR-8487	STAD	TCGA	SSGRVPTI	DEG_COP1_1	849:856	Mutation rewiring degron network	0.25
p.R846Q	TCGA-BR-8487	STAD	TCGA	LMATPNLS	DEG_SCF_FBW7_1	833:840	Mutation rewiring degron network	0.1667
p.R846Q	TCGA-EE-A2GO	SKCM	TCGA	SSGRVPTI	DEG_COP1_1	849:856	Mutation rewiring degron network	0.25
p.R846Q	TCGA-EE-A2GO	SKCM	TCGA	LMATPNLS	DEG_SCF_FBW7_1	833:840	Mutation rewiring degron network	0.1667
p.R846Q	DO50970	LICA	ICGC	SSGRVPTI	DEG_COP1_1	849:856	Mutation rewiring degron network	0.25
p.R846Q	DO50970	LICA	ICGC	LMATPNLS	DEG_SCF_FBW7_1	833:840	Mutation rewiring degron network	0.1667
p.R846Q	DO37823	SKCM	ICGC	SSGRVPTI	DEG_COP1_1	849:856	Mutation rewiring degron network	0.25
p.R846Q	DO37823	SKCM	ICGC	LMATPNLS	DEG_SCF_FBW7_1	833:840	Mutation rewiring degron network	0.1667
p.R846Q	DO47867	STAD	ICGC	SSGRVPTI	DEG_COP1_1	849:856	Mutation rewiring degron network	0.25
p.R846Q	DO47867	STAD	ICGC	LMATPNLS	DEG_SCF_FBW7_1	833:840	Mutation rewiring degron network	0.1667
p.L833F	TCGA-CA-6717	COAD	TCGA	LMATPNLS	DEG_SCF_FBW7_1	833:840	Mutation altering degron motif	0.6981
p.L833F	DO8264	COAD	ICGC	LMATPNLS	DEG_SCF_FBW7_1	833:840	Mutation altering degron motif	0.6981
p.G273W	TCGA-CR-7402	HNSC	TCGA	VPSTPSTS	DEG_SCF_FBW7_1	282:289	Mutation rewiring degron network	0.0833
p.G273W	DO15727	HNSC	ICGC	VPSTPSTS	DEG_SCF_FBW7_1	282:289	Mutation rewiring degron network	0.0833
p.E829K	TCGA-D3-A5GU	SKCM	TCGA	LMATPNLS	DEG_SCF_FBW7_1	833:840	Mutation rewiring degron network	0.2222
p.E829K	DO47584	SKCM	ICGC	LMATPNLS	DEG_SCF_FBW7_1	833:840	Mutation rewiring degron network	0.2222
p.V832M	TCGA-D5-6928	COAD	TCGA	LMATPNLS	DEG_SCF_FBW7_1	833:840	Mutation rewiring degron network	0.3056
p.V832M	DO7776	COAD	ICGC	LMATPNLS	DEG_SCF_FBW7_1	833:840	Mutation rewiring degron network	0.3056
p.V832M	DO234199	ESAD	ICGC	LMATPNLS	DEG_SCF_FBW7_1	833:840	Mutation rewiring degron network	0.3056
p.V832M	SIDM01653	Non-Cancerous	GDSC	LMATPNLS	DEG_SCF_FBW7_1	833:840	Mutation rewiring degron network	0.3056
p.V832M	SIDM00207	Glioblastoma	GDSC	LMATPNLS	DEG_SCF_FBW7_1	833:840	Mutation rewiring degron network	0.3056
p.V832M	SIDM00217	Colorectal Carcinoma	GDSC	LMATPNLS	DEG_SCF_FBW7_1	833:840	Mutation rewiring degron network	0.3056
p.V832M	SIDM01394	Kidney Carcinoma	GDSC	LMATPNLS	DEG_SCF_FBW7_1	833:840	Mutation rewiring degron network	0.3056
p.S279F	TCGA-DA-A1HW	SKCM	TCGA	VPSTPSTS	DEG_SCF_FBW7_1	282:289	Mutation rewiring degron network	0.25
p.S279F	DO38129	SKCM	ICGC	VPSTPSTS	DEG_SCF_FBW7_1	282:289	Mutation rewiring degron network	0.25
p.N845D	TCGA-DD-A4NN	LIHC	TCGA	SSGRVPTI	DEG_COP1_1	849:856	Mutation rewiring degron network	0.2222
p.N845D	TCGA-DD-A4NN	LIHC	TCGA	LMATPNLS	DEG_SCF_FBW7_1	833:840	Mutation rewiring degron network	0.1944
p.N845D	DO44970	LIHC	ICGC	SSGRVPTI	DEG_COP1_1	849:856	Mutation rewiring degron network	0.2222
p.N845D	DO44970	LIHC	ICGC	LMATPNLS	DEG_SCF_FBW7_1	833:840	Mutation rewiring degron network	0.1944
p.P283L	TCGA-EE-A3AG	SKCM	TCGA	VPSTPSTS	DEG_SCF_FBW7_1	282:289	Mutation altering degron motif	0.6471
p.P283L	DO37471	SKCM	ICGC	VPSTPSTS	DEG_SCF_FBW7_1	282:289	Mutation altering degron motif	0.6471
p.P837H	TCGA-FS-A1ZM	SKCM	TCGA	LMATPNLS	DEG_SCF_FBW7_1	833:840	Mutation altering degron motif	0.7694
p.P837H	DO37731	SKCM	ICGC	LMATPNLS	DEG_SCF_FBW7_1	833:840	Mutation altering degron motif	0.7694
p.S289N	TCGA-G4-6628	COAD	TCGA	VPSTPSTS	DEG_SCF_FBW7_1	282:289	Mutation altering degron motif	0.7069
p.S289N	DO10132	COAD	ICGC	VPSTPSTS	DEG_SCF_FBW7_1	282:289	Mutation altering degron motif	0.7069
p.N848S	TCGA-RC-A6M6	LIHC	TCGA	SSGRVPTI	DEG_COP1_1	849:856	Mutation rewiring degron network	0.3056
p.N848S	TCGA-RC-A6M6	LIHC	TCGA	LMATPNLS	DEG_SCF_FBW7_1	833:840	Mutation rewiring degron network	0.1111
p.N848S	DO223917	LIHC	ICGC	SSGRVPTI	DEG_COP1_1	849:856	Mutation rewiring degron network	0.3056
p.N848S	DO223917	LIHC	ICGC	LMATPNLS	DEG_SCF_FBW7_1	833:840	Mutation rewiring degron network	0.1111
p.S274N	DO11854	GBM	ICGC	VPSTPSTS	DEG_SCF_FBW7_1	282:289	Mutation rewiring degron network	0.1111
p.G825V	DO228978	LICA	ICGC	LMATPNLS	DEG_SCF_FBW7_1	833:840	Mutation rewiring degron network	0.1111
p.S290W	DO224541	LUSC	ICGC	VPSTPSTS	DEG_SCF_FBW7_1	282:289	Mutation rewiring degron network	0.3056
p.S287I	DO52659	MALY	ICGC	VPSTPSTS	DEG_SCF_FBW7_1	282:289	Mutation altering degron motif	0.623
p.R830H	SIDM01300	Colorectal Carcinoma	GDSC	LMATPNLS	DEG_SCF_FBW7_1	833:840	Mutation rewiring degron network	0.25
p.G851W	SIDM00119	Non-Small Cell Lung Carcinoma	GDSC	SSGRVPTI	DEG_COP1_1	849:856	Mutation altering degron motif	0.6714
p.G851W	EKVX	lung	COSMIC	SSGRVPTI	DEG_COP1_1	849:856	Mutation altering degron motif	0.6714
p.R294W	SIDM00630	Breast Carcinoma	GDSC	VPSTPSTS	DEG_SCF_FBW7_1	282:289	Mutation rewiring degron network	0.1944
p.R294W	MDA-MB-415	breast	COSMIC	VPSTPSTS	DEG_SCF_FBW7_1	282:289	Mutation rewiring degron network	0.1944
p.Y824C	SIDM01045	Endometrial Carcinoma	GDSC	LMATPNLS	DEG_SCF_FBW7_1	833:840	Mutation rewiring degron network	0.0833
p.Y824C	EN	endometrium	COSMIC	LMATPNLS	DEG_SCF_FBW7_1	833:840	Mutation rewiring degron network	0.0833
p.V282F	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	VPSTPSTS	DEG_SCF_FBW7_1	282:289	Mutation altering degron motif	0.7068
p.V282F	ACH-000672	Lung Cancer	CCLE	VPSTPSTS	DEG_SCF_FBW7_1	282:289	Mutation altering degron motif	0.7068
p.V282F	IA-LM	lung	COSMIC	VPSTPSTS	DEG_SCF_FBW7_1	282:289	Mutation altering degron motif	0.7068
p.P854T	SIDM00115	Head and Neck Carcinoma	GDSC	SSGRVPTI	DEG_COP1_1	849:856	Mutation altering degron motif	0.7031
p.P854T	PCI-6A	upper aerodigestive tract	COSMIC	SSGRVPTI	DEG_COP1_1	849:856	Mutation altering degron motif	0.7031
p.N838S	SIDM01743	Melanoma	GDSC	LMATPNLS	DEG_SCF_FBW7_1	833:840	Mutation altering degron motif	0.5958
p.A283V	TE-11	oesophagus	COSMIC	VPSTPSTS	DEG_SCF_FBW7_1	282:289	Mutation altering degron motif	0.6936
p.L299Q	HCT-15	large intestine	COSMIC	VPSTPSTS	DEG_SCF_FBW7_1	282:289	Mutation rewiring degron network	0.0556
p.S834C	PCI-15A	upper aerodigestive tract	COSMIC	LMATPNLS	DEG_SCF_FBW7_1	833:840	Mutation altering degron motif	0.7541

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AGAP1

UniProt ID: Q9UPQ3

Entrez ID: 116987

Protein name: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 (AGAP-1) (Centaurin-gamma-2) (Cnt-g2) (GTP-binding and GTPase-activating protein 1) (GGAP1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AGAP1 in