DegronMD

Uniprot ID: Q9UPQ3

Source protein: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

Source gene: AGAP1

Class: DEG_COP1_1

Location: 849:856

E3 ligase: COP1

DEGRON score: 0.6448

ASA_SCORE: 85.1375

COIL: 0.9015

CONS_SCORE: 0.2825

DSS_SCORE: 0.7712

HELIX: 0.0391

FCONS_SCORE: 0.8944

RIG_SCORE: 0.6899

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R846Q	TCGA-BR-8487	STAD	TCGA	SSGRVPTI	DEG_COP1_1	0.25
p.R846Q	TCGA-EE-A2GO	SKCM	TCGA	SSGRVPTI	DEG_COP1_1	0.25
p.R846Q	DO50970	LICA	ICGC	SSGRVPTI	DEG_COP1_1	0.25
p.R846Q	DO37823	SKCM	ICGC	SSGRVPTI	DEG_COP1_1	0.25
p.R846Q	DO47867	STAD	ICGC	SSGRVPTI	DEG_COP1_1	0.25
p.N845D	TCGA-DD-A4NN	LIHC	TCGA	SSGRVPTI	DEG_COP1_1	0.2222
p.N845D	DO44970	LIHC	ICGC	SSGRVPTI	DEG_COP1_1	0.2222
p.N848S	TCGA-RC-A6M6	LIHC	TCGA	SSGRVPTI	DEG_COP1_1	0.3056
p.N848S	DO223917	LIHC	ICGC	SSGRVPTI	DEG_COP1_1	0.3056
p.G851W	SIDM00119	Non-Small Cell Lung Carcinoma	GDSC	SSGRVPTI	DEG_COP1_1	0.6714
p.G851W	EKVX	lung	COSMIC	SSGRVPTI	DEG_COP1_1	0.6714
p.P854T	SIDM00115	Head and Neck Carcinoma	GDSC	SSGRVPTI	DEG_COP1_1	0.7031
p.P854T	PCI-6A	upper_aerodigestive_tract	COSMIC	SSGRVPTI	DEG_COP1_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPQ3	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1	DEG_COP1_1	849:856	SSGRVPTI	COP1	0.6448	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons