DegronMD

Uniprot ID: Q9UPQ3

Source protein: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

Source gene: AGAP1

Class: DEG_SCF_FBW7_1

Location: 282:289

E3 ligase: FBXW7

DEGRON score: 0.9931

ASA_SCORE: 79.575

COIL: 0.9428

CONS_SCORE: 0.3656

DSS_SCORE: 0.621

HELIX: 0.0308

FCONS_SCORE: 0.9571

RIG_SCORE: 0.5696

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D277N	TCGA-A5-A0G2	UCEC	TCGA	VPSTPSTS	DEG_SCF_FBW7_1	0.1944
p.D277N	DO41235	UCEC	ICGC	VPSTPSTS	DEG_SCF_FBW7_1	0.1944
p.D296N	TCGA-AG-A002	READ	TCGA	VPSTPSTS	DEG_SCF_FBW7_1	0.1389
p.D296N	TCGA-CA-6717	COAD	TCGA	VPSTPSTS	DEG_SCF_FBW7_1	0.1389
p.D296N	DO8264	COAD	ICGC	VPSTPSTS	DEG_SCF_FBW7_1	0.1389
p.G273W	TCGA-CR-7402	HNSC	TCGA	VPSTPSTS	DEG_SCF_FBW7_1	0.0833
p.G273W	DO15727	HNSC	ICGC	VPSTPSTS	DEG_SCF_FBW7_1	0.0833
p.S279F	TCGA-DA-A1HW	SKCM	TCGA	VPSTPSTS	DEG_SCF_FBW7_1	0.25
p.S279F	DO38129	SKCM	ICGC	VPSTPSTS	DEG_SCF_FBW7_1	0.25
p.P283L	TCGA-EE-A3AG	SKCM	TCGA	VPSTPSTS	DEG_SCF_FBW7_1	0.6471
p.P283L	DO37471	SKCM	ICGC	VPSTPSTS	DEG_SCF_FBW7_1	0.6471
p.S289N	TCGA-G4-6628	COAD	TCGA	VPSTPSTS	DEG_SCF_FBW7_1	0.7069
p.S289N	DO10132	COAD	ICGC	VPSTPSTS	DEG_SCF_FBW7_1	0.7069
p.S274N	DO11854	GBM	ICGC	VPSTPSTS	DEG_SCF_FBW7_1	0.1111
p.S290W	DO224541	LUSC	ICGC	VPSTPSTS	DEG_SCF_FBW7_1	0.3056
p.S287I	DO52659	MALY	ICGC	VPSTPSTS	DEG_SCF_FBW7_1	0.623
p.R294W	SIDM00630	Breast Carcinoma	GDSC	VPSTPSTS	DEG_SCF_FBW7_1	0.1944
p.R294W	MDA-MB-415	breast	COSMIC	VPSTPSTS	DEG_SCF_FBW7_1	0.1944
p.V282F	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	VPSTPSTS	DEG_SCF_FBW7_1	0.7068
p.V282F	ACH-000672	Lung Cancer	CCLE	VPSTPSTS	DEG_SCF_FBW7_1	0.7068
p.V282F	IA-LM	lung	COSMIC	VPSTPSTS	DEG_SCF_FBW7_1	0.7068
p.A283V	TE-11	oesophagus	COSMIC	VPSTPSTS	DEG_SCF_FBW7_1	0.6936
p.L299Q	HCT-15	large_intestine	COSMIC	VPSTPSTS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPQ3	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1	DEG_SCF_FBW7_1	282:289	VPSTPSTS	FBXW7	0.9931	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons