DegronMD

Uniprot ID: Q9NW68

Source protein: BSD domain-containing protein 1

Source gene: BSDC1

Class: DEG_SCF_FBW7_1

Location: 104:111

E3 ligase: FBXW7

DEGRON score: 0.9911

ASA_SCORE: 70.325

COIL: 0.7451

CONS_SCORE: 0.2453

DSS_SCORE: 0.396

HELIX: 0.0371

FCONS_SCORE: 0.8301

RIG_SCORE: 0.7127

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P110S	TCGA-AA-3663	COAD	TCGA	LMGTPSGT	DEG_SCF_FBW7_1	0.6752
p.V101M	TCGA-AR-A0TU	BRCA	TCGA	LMGTPSGT	DEG_SCF_FBW7_1	0.25
p.V118G	TCGA-FI-A2D5	UCEC	TCGA	LMGTPSGT	DEG_SCF_FBW7_1	0.1389
p.P108L	TCGA-UF-A7J9	HNSC	TCGA	LMGTPSGT	DEG_SCF_FBW7_1	0.7582
p.P108L	DO8264	COAD	ICGC	LMGTPSGT	DEG_SCF_FBW7_1	0.7582
p.S112Y	DO19028	KIRC	ICGC	LMGTPSGT	DEG_SCF_FBW7_1	0.3056
p.P108S	DO51266	SKCM	ICGC	LMGTPSGT	DEG_SCF_FBW7_1	0.6752
p.V101G	DO41331	UCEC	ICGC	LMGTPSGT	DEG_SCF_FBW7_1	0.25
p.R121C	ACH-000198	Leukemia	CCLE	LMGTPSGT	DEG_SCF_FBW7_1	0.0556
p.R121C	EoL-1-cell	haematopoietic_and_lymphoid_tissue	COSMIC	LMGTPSGT	DEG_SCF_FBW7_1	0.0556
p.K119T	MOG-G-CCM	central_nervous_system	COSMIC	LMGTPSGT	DEG_SCF_FBW7_1	0.2222
p.A111T	LoVo	large_intestine	COSMIC	LMGTPSGT	DEG_SCF_FBW7_1	0.7139
p.R108Q	22RV1	prostate	COSMIC	LMGTPSGT	DEG_SCF_FBW7_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NW68	BSD domain-containing protein 1	DEG_SCF_FBW7_1	104:111	LMGTPSGT	FBXW7	0.9911	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons