DegronMD

Uniprot ID: Q9ULZ9

Source protein: Matrix metalloproteinase-17

Source gene: MMP17

Class: DEG_SCF_FBW7_1

Location: 104:111

E3 ligase: FBXW7

DEGRON score: 0.6736

ASA_SCORE: 62.275

COIL: 0.5648

CONS_SCORE: 0.6506

DSS_SCORE: 0.2861

HELIX: 0.3673

FCONS_SCORE: 1.3543

RIG_SCORE: 0.7918

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H110N	DO41752	UCEC	ICGC	LMKTPRCS	DEG_SCF_FBW7_1	0.7423
p.T107S	ACH-001610	Brain Cancer	CCLE	LMKTPRCS	DEG_SCF_FBW7_1	0.7116
p.T107P	TCGA-4R-AA8I	LIHC	TCGA	LMKTPRCS	DEG_SCF_FBW7_1	0.7031
p.D104N	DO228551	GACA	ICGC	LMKTPRCS	DEG_SCF_FBW7_1	0.6932
p.D104N	DO42713	UCEC	ICGC	LMKTPRCS	DEG_SCF_FBW7_1	0.6932
p.N111K	NCI-H1688	lung	COSMIC	LMKTPRCS	DEG_SCF_FBW7_1	0.6918
p.A99T	DO3686	BRCA	ICGC	LMKTPRCS	DEG_SCF_FBW7_1	0.1944
p.A98T	DO230334	COCA	ICGC	LMKTPRCS	DEG_SCF_FBW7_1	0.1667
p.A98T	DO229016	COCA	ICGC	LMKTPRCS	DEG_SCF_FBW7_1	0.1667
p.A98T	DO229003	COCA	ICGC	LMKTPRCS	DEG_SCF_FBW7_1	0.1667
p.A98T	DO228142	PBCA	ICGC	LMKTPRCS	DEG_SCF_FBW7_1	0.1667
p.A98S	DO229035	LICA	ICGC	LMKTPRCS	DEG_SCF_FBW7_1	0.1667
p.D117N	DO41584	UCEC	ICGC	LMKTPRCS	DEG_SCF_FBW7_1	0.1667
p.Q120K	TCGA-D3-A2J8	SKCM	TCGA	LMKTPRCS	DEG_SCF_FBW7_1	0.0833
p.A95V	DO229051	LICA	ICGC	LMKTPRCS	DEG_SCF_FBW7_1	0.0833
p.A95V	NCI-H1105	lung	COSMIC	LMKTPRCS	DEG_SCF_FBW7_1	0.0833
p.G121R	DO24596	LUAD	ICGC	LMKTPRCS	DEG_SCF_FBW7_1	0.0556
p.A121V	SIDM00217	Colorectal Carcinoma	GDSC	LMKTPRCS	DEG_SCF_FBW7_1	0.0556
p.A121V	ACH-000999	Colon/Colorectal Cancer	CCLE	LMKTPRCS	DEG_SCF_FBW7_1	0.0556
p.A121V	SNU-1040	large_intestine	COSMIC	LMKTPRCS	DEG_SCF_FBW7_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULZ9	Matrix metalloproteinase-17	DEG_SCF_FBW7_1	104:111	LMKTPRCS	FBXW7	0.6736	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons