DegronMD - Q9ULZ9(MMP17)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T107P	TCGA-4R-AA8I	LIHC	TCGA	LMKTPRCS	DEG_SCF_FBW7_1	104:111	Mutation altering degron motif	0.7031
p.R125H	TCGA-A5-A0G1	UCEC	TCGA	PRCSLPDLP	DEG_APCC_DBOX_1	108:116	Mutation rewiring degron network	0.0833
p.L115I	TCGA-AX-A2HC	UCEC	TCGA	PRCSLPDLP	DEG_APCC_DBOX_1	108:116	Mutation altering degron motif	0.6063
p.R125C	TCGA-AZ-6607	COAD	TCGA	PRCSLPDLP	DEG_APCC_DBOX_1	108:116	Mutation rewiring degron network	0.0833
p.Q120K	TCGA-D3-A2J8	SKCM	TCGA	PRCSLPDLP	DEG_APCC_DBOX_1	108:116	Mutation rewiring degron network	0.2222
p.Q120K	TCGA-D3-A2J8	SKCM	TCGA	LMKTPRCS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.0833
p.P116S	TCGA-EO-A22U	UCEC	TCGA	PRCSLPDLP	DEG_APCC_DBOX_1	108:116	Mutation altering degron motif	0.5641
p.A99T	DO3686	BRCA	ICGC	PRCSLPDLP	DEG_APCC_DBOX_1	108:116	Mutation rewiring degron network	0.0833
p.A99T	DO3686	BRCA	ICGC	LMKTPRCS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.1944
p.A98T	DO230334	COCA	ICGC	PRCSLPDLP	DEG_APCC_DBOX_1	108:116	Mutation rewiring degron network	0.0556
p.A98T	DO230334	COCA	ICGC	LMKTPRCS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.1667
p.A98T	DO229016	COCA	ICGC	PRCSLPDLP	DEG_APCC_DBOX_1	108:116	Mutation rewiring degron network	0.0556
p.A98T	DO229016	COCA	ICGC	LMKTPRCS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.1667
p.A98T	DO229003	COCA	ICGC	PRCSLPDLP	DEG_APCC_DBOX_1	108:116	Mutation rewiring degron network	0.0556
p.A98T	DO229003	COCA	ICGC	LMKTPRCS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.1667
p.A98T	DO228142	PBCA	ICGC	PRCSLPDLP	DEG_APCC_DBOX_1	108:116	Mutation rewiring degron network	0.0556
p.A98T	DO228142	PBCA	ICGC	LMKTPRCS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.1667
p.D104N	DO228551	GACA	ICGC	LMKTPRCS	DEG_SCF_FBW7_1	104:111	Mutation altering degron motif	0.6932
p.D104N	DO42713	UCEC	ICGC	LMKTPRCS	DEG_SCF_FBW7_1	104:111	Mutation altering degron motif	0.6932
p.A98S	DO229035	LICA	ICGC	PRCSLPDLP	DEG_APCC_DBOX_1	108:116	Mutation rewiring degron network	0.0556
p.A98S	DO229035	LICA	ICGC	LMKTPRCS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.1667
p.A95V	DO229051	LICA	ICGC	LMKTPRCS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.0833
p.A95V	NCI-H1105	lung	COSMIC	LMKTPRCS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.0833
p.V123M	DO219515	LIHC	ICGC	PRCSLPDLP	DEG_APCC_DBOX_1	108:116	Mutation rewiring degron network	0.1389
p.V123M	VMRC-RCW	kidney	COSMIC	PRCSLPDLP	DEG_APCC_DBOX_1	108:116	Mutation rewiring degron network	0.1389
p.G121R	DO24596	LUAD	ICGC	PRCSLPDLP	DEG_APCC_DBOX_1	108:116	Mutation rewiring degron network	0.1944
p.G121R	DO24596	LUAD	ICGC	LMKTPRCS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.0556
p.P115L	DO47638	SKCM	ICGC	PRCSLPDLP	DEG_APCC_DBOX_1	108:116	Mutation altering degron motif	0.7582
p.P115L	DO42033	UCEC	ICGC	PRCSLPDLP	DEG_APCC_DBOX_1	108:116	Mutation altering degron motif	0.7582
p.T122I	DO51270	SKCM	ICGC	PRCSLPDLP	DEG_APCC_DBOX_1	108:116	Mutation rewiring degron network	0.1667
p.H110N	DO41752	UCEC	ICGC	PRCSLPDLP	DEG_APCC_DBOX_1	108:116	Mutation altering degron motif	0.7423
p.H110N	DO41752	UCEC	ICGC	LMKTPRCS	DEG_SCF_FBW7_1	104:111	Mutation altering degron motif	0.7423
p.D117N	DO41584	UCEC	ICGC	PRCSLPDLP	DEG_APCC_DBOX_1	108:116	Mutation rewiring degron network	0.3056
p.D117N	DO41584	UCEC	ICGC	LMKTPRCS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.1667
p.A121V	SIDM00217	Colorectal Carcinoma	GDSC	PRCSLPDLP	DEG_APCC_DBOX_1	108:116	Mutation rewiring degron network	0.1944
p.A121V	SIDM00217	Colorectal Carcinoma	GDSC	LMKTPRCS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.0556
p.A121V	ACH-000999	Colon/Colorectal Cancer	CCLE	PRCSLPDLP	DEG_APCC_DBOX_1	108:116	Mutation rewiring degron network	0.1944
p.A121V	ACH-000999	Colon/Colorectal Cancer	CCLE	LMKTPRCS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.0556
p.A121V	SNU-1040	large intestine	COSMIC	PRCSLPDLP	DEG_APCC_DBOX_1	108:116	Mutation rewiring degron network	0.1944
p.A121V	SNU-1040	large intestine	COSMIC	LMKTPRCS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.0556
p.D114N	ACH-001516	Cervical Cancer	CCLE	PRCSLPDLP	DEG_APCC_DBOX_1	108:116	Mutation altering degron motif	0.5821
p.T107S	ACH-001610	Brain Cancer	CCLE	LMKTPRCS	DEG_SCF_FBW7_1	104:111	Mutation altering degron motif	0.7116
p.N111K	NCI-H1688	lung	COSMIC	PRCSLPDLP	DEG_APCC_DBOX_1	108:116	Mutation altering degron motif	0.6918
p.N111K	NCI-H1688	lung	COSMIC	LMKTPRCS	DEG_SCF_FBW7_1	104:111	Mutation altering degron motif	0.6918

Kaplan plot for MMP17 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MMP17

UniProt ID: Q9ULZ9

Entrez ID: 4326

Protein name: Matrix metalloproteinase-17 (MMP-17) (EC 3.4.24.-) (Membrane-type matrix metalloproteinase 4) (MT-MMP 4) (MTMMP4) (Membrane-type-4 matrix metalloproteinase) (MT4-MMP) (MT4MMP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MMP17 in