DegronMD

Uniprot ID: Q9ULZ9

Source protein: Matrix metalloproteinase-17

Source gene: MMP17

Class: DEG_APCC_DBOX_1

Location: 108:116

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.986

ASA_SCORE: 62.2556

COIL: 0.7922

CONS_SCORE: 0.6041

DSS_SCORE: 0.3608

HELIX: 0.1243

FCONS_SCORE: 1.3044

RIG_SCORE: 0.78

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R125H	TCGA-A5-A0G1	UCEC	TCGA	PRCSLPDLP	DEG_APCC_DBOX_1	0.0833
p.L115I	TCGA-AX-A2HC	UCEC	TCGA	PRCSLPDLP	DEG_APCC_DBOX_1	0.6063
p.R125C	TCGA-AZ-6607	COAD	TCGA	PRCSLPDLP	DEG_APCC_DBOX_1	0.0833
p.Q120K	TCGA-D3-A2J8	SKCM	TCGA	PRCSLPDLP	DEG_APCC_DBOX_1	0.2222
p.P116S	TCGA-EO-A22U	UCEC	TCGA	PRCSLPDLP	DEG_APCC_DBOX_1	0.5641
p.A99T	DO3686	BRCA	ICGC	PRCSLPDLP	DEG_APCC_DBOX_1	0.0833
p.A98T	DO230334	COCA	ICGC	PRCSLPDLP	DEG_APCC_DBOX_1	0.0556
p.A98T	DO229016	COCA	ICGC	PRCSLPDLP	DEG_APCC_DBOX_1	0.0556
p.A98T	DO229003	COCA	ICGC	PRCSLPDLP	DEG_APCC_DBOX_1	0.0556
p.A98T	DO228142	PBCA	ICGC	PRCSLPDLP	DEG_APCC_DBOX_1	0.0556
p.A98S	DO229035	LICA	ICGC	PRCSLPDLP	DEG_APCC_DBOX_1	0.0556
p.V123M	DO219515	LIHC	ICGC	PRCSLPDLP	DEG_APCC_DBOX_1	0.1389
p.V123M	VMRC-RCW	kidney	COSMIC	PRCSLPDLP	DEG_APCC_DBOX_1	0.1389
p.G121R	DO24596	LUAD	ICGC	PRCSLPDLP	DEG_APCC_DBOX_1	0.1944
p.P115L	DO47638	SKCM	ICGC	PRCSLPDLP	DEG_APCC_DBOX_1	0.7582
p.P115L	DO42033	UCEC	ICGC	PRCSLPDLP	DEG_APCC_DBOX_1	0.7582
p.T122I	DO51270	SKCM	ICGC	PRCSLPDLP	DEG_APCC_DBOX_1	0.1667
p.H110N	DO41752	UCEC	ICGC	PRCSLPDLP	DEG_APCC_DBOX_1	0.7423
p.D117N	DO41584	UCEC	ICGC	PRCSLPDLP	DEG_APCC_DBOX_1	0.3056
p.A121V	SIDM00217	Colorectal Carcinoma	GDSC	PRCSLPDLP	DEG_APCC_DBOX_1	0.1944
p.A121V	ACH-000999	Colon/Colorectal Cancer	CCLE	PRCSLPDLP	DEG_APCC_DBOX_1	0.1944
p.A121V	SNU-1040	large_intestine	COSMIC	PRCSLPDLP	DEG_APCC_DBOX_1	0.1944
p.D114N	ACH-001516	Cervical Cancer	CCLE	PRCSLPDLP	DEG_APCC_DBOX_1	0.5821
p.N111K	NCI-H1688	lung	COSMIC	PRCSLPDLP	DEG_APCC_DBOX_1	0.6918

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULZ9	Matrix metalloproteinase-17	DEG_APCC_DBOX_1	108:116	PRCSLPDLP	APC,CDC20,FZR1	0.986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons