DegronMD

Uniprot ID: Q6P5X7

Source protein: Transmembrane protein 71

Source gene: TMEM71

Class: DEG_SCF_FBW7_1

Location: 7:14

E3 ligase: FBXW7

DEGRON score: 0.9303

ASA_SCORE: 67.65

COIL: 0.7494

CONS_SCORE: 0.7574

DSS_SCORE: 0.3659

HELIX: 0.1743

FCONS_SCORE: 1.518

RIG_SCORE: 0.7315

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q6E	TCGA-05-4397	LUAD	TCGA	LMSTPVAS	DEG_SCF_FBW7_1	0.3056
p.Q6E	TCGA-AR-A250	BRCA	TCGA	LMSTPVAS	DEG_SCF_FBW7_1	0.3056
p.Q6E	TCGA-GV-A3JZ	BLCA	TCGA	LMSTPVAS	DEG_SCF_FBW7_1	0.3056
p.Q6E	DO773	BLCA	ICGC	LMSTPVAS	DEG_SCF_FBW7_1	0.3056
p.Q6E	DO1802	BRCA	ICGC	LMSTPVAS	DEG_SCF_FBW7_1	0.3056
p.Q6E	DO25320	LUAD	ICGC	LMSTPVAS	DEG_SCF_FBW7_1	0.3056
p.R3Q	TCGA-B5-A0JY	UCEC	TCGA	LMSTPVAS	DEG_SCF_FBW7_1	0.2222
p.R3Q	TCGA-SW-A7EB	STAD	TCGA	LMSTPVAS	DEG_SCF_FBW7_1	0.2222
p.R3Q	DO220895	MELA	ICGC	LMSTPVAS	DEG_SCF_FBW7_1	0.2222
p.R3Q	DO50143	STAD	ICGC	LMSTPVAS	DEG_SCF_FBW7_1	0.2222
p.R3Q	DO43041	UCEC	ICGC	LMSTPVAS	DEG_SCF_FBW7_1	0.2222
p.G24R	DO222494	MELA	ICGC	LMSTPVAS	DEG_SCF_FBW7_1	0.0556
p.R3L	SIDM00660	Colorectal Carcinoma	GDSC	LMSTPVAS	DEG_SCF_FBW7_1	0.2222
p.R3L	ACH-000985	Colon/Colorectal Cancer	CCLE	LMSTPVAS	DEG_SCF_FBW7_1	0.2222
p.R3L	LS-411N	large_intestine	COSMIC	LMSTPVAS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P5X7	Transmembrane protein 71	DEG_SCF_FBW7_1	7:14	LMSTPVAS	FBXW7	0.9303	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons