DegronMD

Uniprot ID: O00443

Source protein: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

Source gene: PIK3C2A

Class: LIG_APCC_ABBA_1

Location: 75:80

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9988

ASA_SCORE: 69.8

COIL: 0.7145

CONS_SCORE: 0.4041

DSS_SCORE: 0.3872

HELIX: 0.1153

FCONS_SCORE: 1.2053

RIG_SCORE: 0.8052

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V77L	TCGA-66-2765	LUSC	TCGA	LMVFPE	LIG_APCC_ABBA_1	0.5654
p.V77L	DO26761	LUSC	ICGC	LMVFPE	LIG_APCC_ABBA_1	0.5654
p.L75F	TCGA-D1-A103	UCEC	TCGA	LMVFPE	LIG_APCC_ABBA_1	0.587
p.L75F	DO42312	UCEC	ICGC	LMVFPE	LIG_APCC_ABBA_1	0.587
p.P79S	TCGA-EB-A1NK	SKCM	TCGA	LMVFPE	LIG_APCC_ABBA_1	0.5641
p.P79S	DO37695	SKCM	ICGC	LMVFPE	LIG_APCC_ABBA_1	0.5641
p.I71V	DO10276	COAD	ICGC	LMVFPE	LIG_APCC_ABBA_1	0.2222
p.W77L	DO37480	SKCM	ICGC	LMVFPE	LIG_APCC_ABBA_1	0.7015
p.D86E	DO51271	SKCM	ICGC	LMVFPE	LIG_APCC_ABBA_1	0.1667
p.E68K	DO51761	STAD	ICGC	LMVFPE	LIG_APCC_ABBA_1	0.5833
p.D81G	DO47973	STAD	ICGC	LMVFPE	LIG_APCC_ABBA_1	0.3056
p.S65Y	DO43154	UCEC	ICGC	LMVFPE	LIG_APCC_ABBA_1	0.0556
p.I70T	DO42745	UCEC	ICGC	LMVFPE	LIG_APCC_ABBA_1	0.3056
p.V77A	SIDM01045	Endometrial Carcinoma	GDSC	LMVFPE	LIG_APCC_ABBA_1	0.6936
p.V77A	ACH-000978	Endometrial/Uterine Cancer	CCLE	LMVFPE	LIG_APCC_ABBA_1	0.6936
p.V77A	EN	endometrium	COSMIC	LMVFPE	LIG_APCC_ABBA_1	0.6936
p.K70N	SIDM00217	Colorectal Carcinoma	GDSC	LMVFPE	LIG_APCC_ABBA_1	0.3056
p.K70N	ACH-000999	Colon/Colorectal Cancer	CCLE	LMVFPE	LIG_APCC_ABBA_1	0.3056
p.K70N	SNU-1040	large_intestine	COSMIC	LMVFPE	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00443	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	LIG_APCC_ABBA_1	75:80	LMVFPE	APC,CDC20,FZR1	0.9988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons