DegronMD - O00443(PIK3C2A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V77L	TCGA-66-2765	LUSC	TCGA	LMVFPE	LIG_APCC_ABBA_1	75:80	Mutation altering degron motif	0.5654
p.V77L	DO26761	LUSC	ICGC	LMVFPE	LIG_APCC_ABBA_1	75:80	Mutation altering degron motif	0.5654
p.E110K	TCGA-D1-A103	UCEC	TCGA	LPVTPILS	DEG_SCF_FBW7_1	117:124	Mutation rewiring degron network	0.1389
p.E110K	DO42312	UCEC	ICGC	LPVTPILS	DEG_SCF_FBW7_1	117:124	Mutation rewiring degron network	0.1389
p.L75F	TCGA-D1-A103	UCEC	TCGA	LMVFPE	LIG_APCC_ABBA_1	75:80	Mutation altering degron motif	0.587
p.L75F	DO42312	UCEC	ICGC	LMVFPE	LIG_APCC_ABBA_1	75:80	Mutation altering degron motif	0.587
p.T114A	TCGA-D1-A16Y	UCEC	TCGA	LPVTPILS	DEG_SCF_FBW7_1	117:124	Mutation rewiring degron network	0.25
p.T114A	DO41524	UCEC	ICGC	LPVTPILS	DEG_SCF_FBW7_1	117:124	Mutation rewiring degron network	0.25
p.K113Q	TCGA-DJ-A1QE	THCA	TCGA	LPVTPILS	DEG_SCF_FBW7_1	117:124	Mutation substituting flanking lysine	0.3333
p.K113Q	DO40369	THCA	ICGC	LPVTPILS	DEG_SCF_FBW7_1	117:124	Mutation substituting flanking lysine	0.3333
p.P79S	TCGA-EB-A1NK	SKCM	TCGA	LMVFPE	LIG_APCC_ABBA_1	75:80	Mutation altering degron motif	0.5641
p.P79S	DO37695	SKCM	ICGC	LMVFPE	LIG_APCC_ABBA_1	75:80	Mutation altering degron motif	0.5641
p.S128L	TCGA-YC-A89H	BLCA	TCGA	LPVTPILS	DEG_SCF_FBW7_1	117:124	Mutation rewiring degron network	0.2222
p.S128L	DO51948	BLCA	ICGC	LPVTPILS	DEG_SCF_FBW7_1	117:124	Mutation rewiring degron network	0.2222
p.I71V	DO10276	COAD	ICGC	LMVFPE	LIG_APCC_ABBA_1	75:80	Mutation rewiring degron network	0.2222
p.K118T	DO222884	COCA	ICGC	LPVTPILS	DEG_SCF_FBW7_1	117:124	Mutation altering degron motif	0.7306
p.D120E	DO228986	LICA	ICGC	LPVTPILS	DEG_SCF_FBW7_1	117:124	Mutation altering degron motif	0.6758
p.L131I	DO229045	LICA	ICGC	LPVTPILS	DEG_SCF_FBW7_1	117:124	Mutation rewiring degron network	0.1389
p.Q126K	DO229008	LICA	ICGC	LPVTPILS	DEG_SCF_FBW7_1	117:124	Mutation blocking phosphorylation signal	0.7222
p.K112E	DO44664	LICA	ICGC	LPVTPILS	DEG_SCF_FBW7_1	117:124	Mutation blocking ubiquitination signal	0.6389
p.I123L	DO50776	LIRI	ICGC	LPVTPILS	DEG_SCF_FBW7_1	117:124	Mutation altering degron motif	0.7174
p.S131C	DO27413	LUSC	ICGC	LPVTPILS	DEG_SCF_FBW7_1	117:124	Mutation rewiring degron network	0.1389
p.W77L	DO37480	SKCM	ICGC	LMVFPE	LIG_APCC_ABBA_1	75:80	Mutation altering degron motif	0.7015
p.L107I	DO47578	SKCM	ICGC	LPVTPILS	DEG_SCF_FBW7_1	117:124	Mutation rewiring degron network	0.0556
p.D86E	DO51271	SKCM	ICGC	LMVFPE	LIG_APCC_ABBA_1	75:80	Mutation rewiring degron network	0.1667
p.E68K	DO51761	STAD	ICGC	LMVFPE	LIG_APCC_ABBA_1	75:80	Mutation blocking phosphorylation signal	0.5833
p.D81G	DO47973	STAD	ICGC	LMVFPE	LIG_APCC_ABBA_1	75:80	Mutation rewiring degron network	0.3056
p.S65Y	DO43154	UCEC	ICGC	LMVFPE	LIG_APCC_ABBA_1	75:80	Mutation rewiring degron network	0.0556
p.I70T	DO42745	UCEC	ICGC	LMVFPE	LIG_APCC_ABBA_1	75:80	Mutation substituting flanking lysine	0.3056
p.F133L	SIDM00683	Prostate Carcinoma	GDSC	LPVTPILS	DEG_SCF_FBW7_1	117:124	Mutation rewiring degron network	0.0833
p.F133L	SIDM00594	Acute Myeloid Leukemia	GDSC	LPVTPILS	DEG_SCF_FBW7_1	117:124	Mutation rewiring degron network	0.0833
p.F133L	SIDM01051	Ovarian Carcinoma	GDSC	LPVTPILS	DEG_SCF_FBW7_1	117:124	Mutation rewiring degron network	0.0833
p.F133L	SIDM00126	Melanoma	GDSC	LPVTPILS	DEG_SCF_FBW7_1	117:124	Mutation rewiring degron network	0.0833
p.T111A	SIDM00258	Neuroblastoma	GDSC	LPVTPILS	DEG_SCF_FBW7_1	117:124	Mutation rewiring degron network	0.1667
p.T111A	NB12	autonomic ganglia	COSMIC	LPVTPILS	DEG_SCF_FBW7_1	117:124	Mutation rewiring degron network	0.1667
p.V77A	SIDM01045	Endometrial Carcinoma	GDSC	LMVFPE	LIG_APCC_ABBA_1	75:80	Mutation altering degron motif	0.6936
p.V77A	ACH-000978	Endometrial/Uterine Cancer	CCLE	LMVFPE	LIG_APCC_ABBA_1	75:80	Mutation altering degron motif	0.6936
p.V77A	EN	endometrium	COSMIC	LMVFPE	LIG_APCC_ABBA_1	75:80	Mutation altering degron motif	0.6936
p.K70N	SIDM00217	Colorectal Carcinoma	GDSC	LMVFPE	LIG_APCC_ABBA_1	75:80	Mutation substituting flanking lysine	0.3056
p.K70N	ACH-000999	Colon/Colorectal Cancer	CCLE	LMVFPE	LIG_APCC_ABBA_1	75:80	Mutation substituting flanking lysine	0.3056
p.K70N	SNU-1040	large intestine	COSMIC	LMVFPE	LIG_APCC_ABBA_1	75:80	Mutation substituting flanking lysine	0.3056
p.F133C	SIDM01450	Gastric Carcinoma	GDSC	LPVTPILS	DEG_SCF_FBW7_1	117:124	Mutation rewiring degron network	0.0833
p.F133C	ACH-000898	Gastric Cancer	CCLE	LPVTPILS	DEG_SCF_FBW7_1	117:124	Mutation rewiring degron network	0.0833
p.S124N	ACH-001354	Neuroblastoma	CCLE	LPVTPILS	DEG_SCF_FBW7_1	117:124	Mutation altering degron motif	0.818

Kaplan plot for PIK3C2A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PIK3C2A

UniProt ID: O00443

Entrez ID: 5286

Protein name: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PI3K-C2-alpha) (PtdIns-3-kinase C2 subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-alpha)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PIK3C2A in