DegronMD

Uniprot ID: O00443

Source protein: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

Source gene: PIK3C2A

Class: DEG_SCF_FBW7_1

Location: 117:124

E3 ligase: FBXW7

DEGRON score: 0.997

ASA_SCORE: 68.4875

COIL: 0.923

CONS_SCORE: 0.3764

DSS_SCORE: 0.2662

HELIX: 0.0224

FCONS_SCORE: 1.0646

RIG_SCORE: 0.7989

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E110K	TCGA-D1-A103	UCEC	TCGA	LPVTPILS	DEG_SCF_FBW7_1	0.1389
p.E110K	DO42312	UCEC	ICGC	LPVTPILS	DEG_SCF_FBW7_1	0.1389
p.T114A	TCGA-D1-A16Y	UCEC	TCGA	LPVTPILS	DEG_SCF_FBW7_1	0.25
p.T114A	DO41524	UCEC	ICGC	LPVTPILS	DEG_SCF_FBW7_1	0.25
p.K113Q	TCGA-DJ-A1QE	THCA	TCGA	LPVTPILS	DEG_SCF_FBW7_1	0.3333
p.K113Q	DO40369	THCA	ICGC	LPVTPILS	DEG_SCF_FBW7_1	0.3333
p.S128L	TCGA-YC-A89H	BLCA	TCGA	LPVTPILS	DEG_SCF_FBW7_1	0.2222
p.S128L	DO51948	BLCA	ICGC	LPVTPILS	DEG_SCF_FBW7_1	0.2222
p.K118T	DO222884	COCA	ICGC	LPVTPILS	DEG_SCF_FBW7_1	0.7306
p.D120E	DO228986	LICA	ICGC	LPVTPILS	DEG_SCF_FBW7_1	0.6758
p.L131I	DO229045	LICA	ICGC	LPVTPILS	DEG_SCF_FBW7_1	0.1389
p.Q126K	DO229008	LICA	ICGC	LPVTPILS	DEG_SCF_FBW7_1	0.7222
p.K112E	DO44664	LICA	ICGC	LPVTPILS	DEG_SCF_FBW7_1	0.6389
p.I123L	DO50776	LIRI	ICGC	LPVTPILS	DEG_SCF_FBW7_1	0.7174
p.S131C	DO27413	LUSC	ICGC	LPVTPILS	DEG_SCF_FBW7_1	0.1389
p.L107I	DO47578	SKCM	ICGC	LPVTPILS	DEG_SCF_FBW7_1	0.0556
p.F133L	SIDM00683	Prostate Carcinoma	GDSC	LPVTPILS	DEG_SCF_FBW7_1	0.0833
p.F133L	SIDM00594	Acute Myeloid Leukemia	GDSC	LPVTPILS	DEG_SCF_FBW7_1	0.0833
p.F133L	SIDM01051	Ovarian Carcinoma	GDSC	LPVTPILS	DEG_SCF_FBW7_1	0.0833
p.F133L	SIDM00126	Melanoma	GDSC	LPVTPILS	DEG_SCF_FBW7_1	0.0833
p.T111A	SIDM00258	Neuroblastoma	GDSC	LPVTPILS	DEG_SCF_FBW7_1	0.1667
p.T111A	NB12	autonomic_ganglia	COSMIC	LPVTPILS	DEG_SCF_FBW7_1	0.1667
p.F133C	SIDM01450	Gastric Carcinoma	GDSC	LPVTPILS	DEG_SCF_FBW7_1	0.0833
p.F133C	ACH-000898	Gastric Cancer	CCLE	LPVTPILS	DEG_SCF_FBW7_1	0.0833
p.S124N	ACH-001354	Neuroblastoma	CCLE	LPVTPILS	DEG_SCF_FBW7_1	0.818

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00443	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	DEG_SCF_FBW7_1	117:124	LPVTPILS	FBXW7	0.997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons